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European Biopharmaceutical Review
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Cellular therapies – such as treatment with mesenchymal stem cells (MSCs) or, recently, with genetically adapted T-autologous (Ta) cells – are coming of age and have exhibited their efficacy for selected indications in numerous preclinical trials. Many have received first approvals or are likely to in the near future. MSCs have been approved for selected indications in Canada as well as New Zealand, and at least one chimeric antigen receptor (CAR) T-cell product has gained a unanimous positive review by the FDA advisory committee.
The cross-section of medical devices and cellular therapies has been explored and utilised for some time; for example, cells have been embedded in collagenous foams to secure their location, or catheters have been employed to facilitate targeted delivery of cells.
For biologics and small molecules, this cross-section is perhaps not as clearly visible, yet it has transpired that combinations may yield massive improvements, as demonstrated in preclinical studies. Hence, this appears to be an opportunity worthy of exploration due to its benefits as well as its practical, quality and regulatory implications.
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News and Press Releases |
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Ubiquigent celebrates milestone anniversary of DUBprofiler™ compound profiling platform
Dundee, UK, 14th December 2021 – Today, Ubiquigent Limited (Ubiquigent) celebrates the 10th anniversary of its DUBprofiler™ compound profiling platform, together with KSQ Therapeutics joining its expanding customer base.
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White Papers |
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Nanoparticle Tracking Analysis. A Review of Applications and Usage in the Analysis of Exosomes and Microvesicles
NanoSight
The study of exosomes and other cell-derived microvesicles is
an area of rapidly growing importance and the subject of intense interest and
research. The previous lack of suitable methods for their detection, analysis,
enumeration and phenotyping is proving to be a significant limitation in these
studies. This mini-review shows the degree to which the technique of
Nanoparticle Tracking Analysis (NTA) is helping to address these problems.
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