spacer
home > ebr > autumn 2018 > determining peptides
PUBLICATIONS
European Biopharmaceutical Review

Determining Peptides

Therapeutic peptides are often applied via the following routes: intramuscular (IM), intraperitoneal (IP), intravenous (IV), or inhalative. Only a few peptides are stable in the stomach (acidic plus pepsin digestion) and the intestine (trypsin digestion) after oral application. Determination in plasma is very complex, as far as selectivity is concerned, because millions of endogenous peptides and proteins can be found in plasma.

Usually, the determination of a drug in plasma starts with some questions:

• How much of that drug is applied per kg body weight
• Which route of application is used (IM, IP, IV, oral, or inhalative)
• Is anything known about the first pass effect (leading to metabolites and, therefore, lowering the parent drug concentration)
• Does the molecule show a high volume of bodily distribution (which often means that the molecule shows very lipophilic characteristics or high tissue attraction and, therefore, a fast elimination half-life and low concentration levels in plasma

Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
Professor Hermann Mascher, bioanalytical consultant and founder of pharm-analyt Labor, has more than 100 publications in peer reviewed journals (with more than a 230 impact factor). Hermann is the inventor of three patents for biomarkers in the area of rare lysosomal storage diseases and has developed analytical methods for dozens of peptides.
spacer
Professor Hermann Mascher
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

RSSL introduces same-day mycoplasma testing service in UK

Reading Scientific Services Ltd (RSSL), a leading provider of scientific and technical solutions to the global biopharmaceutical, pharmaceutical, and biopharmaceutical sectors, has introduced the United Kingdom’s first same-day mycoplasma testing service for manufacturers of biologic medicines.
More info >>

White Papers

Bringing more control to temperature-sensitive logistics

UPS Supply Chain Solutions

By 2016, world sales of cold-chain drugs and biologics such as vaccines and blood plasma products will near $240 billion1. The increase has led to a surge in discussion about how to protect these products throughout the transportation logistics cycle. Industry experts are recommending that the term “cold chain” be eliminated from rules, guidance and best-practice documents. “Cold chain” now includes a broader spectrum of temperature ranges, such as controlled room temperature (CRT). This white paper focuses on the initial steps required to establish a temperature-sensitive supply chain.
More info >>

 
Industry Events

Multimodal 2019

18-20 June 2019, NEC, Birmingham, UK

Now in its twelfth year, Multimodal is the UK and Ireland’s premier freight transport, logistics and supply chain management event.  Shippers and cargo owners attend to improve their businesses; by finding ways of moving their products more efficiently and by meeting new suppliers. 
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement