samedan logo
 
 
 
spacer
home > ebr > autumn 2019 > advancing liquid biopsies
PUBLICATIONS
European Biopharmaceutical Review

Advancing Liquid Biopsies




The rise of liquid biopsies has ushered in many exciting new opportunities, particularly in oncology-focused applications relevant to pharmaceutical scientists engaged in drug discovery and development pipelines. While the term ‘liquid biopsy’ has been applied to circulating tumour cells and other analytes, it is generally associated with the analysis of cell-free DNA (cfDNA) that is shed from solid tumours and derived from peripheral blood.

Before the introduction of liquid biopsies, scientists were usually limited to working with tissue biopsy samples. These required invasive, often painful medical procedures and frequently yielded inevaluable samples. The idea of monitoring patients frequently – such as collecting tumour biopsies at every treatment cycle to gauge treatment response – was unthinkable.

Now, scientists can ask questions that have never been possible before and monitor tumour evolution in near real time. Implementing liquid biopsies, requiring only a simple blood draw from patients, has suddenly made it feasible to gather new information from patients on a regular basis and over long periods of time. Thanks to the next-generation sequencing (NGS) technologies used to analyse these blood samples, liquid biopsy assays can have remarkable sensitivity and specificity while evaluating thousands of potential mutation sites. They can detect not only single nucleotide variants and insertions and deletions (indels), but also more complicated mutations such as gene fusions and copy number variations. Already, this has fundamentally changed how researchers can evaluate treatment response, detect tumour progression with the rise of resistance mutations, and monitor patients longitudinally.

Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

 You must be a member of the site to make a comment.
spacer
Mark Li serves as President and CEO of Resolution Bioscience. He is a serial investor and entrepreneur who is now focused on applying startup methodologies from the tech industry to develop better medical devices. Earlier in his career, he founded Yahoo! Europe and was responsible for starting and overseeing engineering operations for Yahoo! in 23 countries. Mark also pioneered early desktop publishing in the book, magazine, and multimedia CD-ROM industry while at Ziff-Davis Publishing. He earned his BSc in zoology/ animal biology from the University of California, US.
spacer
Mark Li
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Protagen Protein Services (PPS) expands capabilities for aggregate analytics to include dynamic light scattering (DLS)

Protein aggregation is a common challenge in the manufacturing of biological products. As one of the most sensitive techniques for the detection of aggregates, dynamic light scattering (DLS) provides a simple, fast and non-destructive testing method. An innovative technique based on a unique cuvette layout allows for accurate measurements with as little as a single µL of solution.
More info >>

White Papers

EU GDP Guidelines: Implications for Shipping Clinical Materials into the European Market

PCI Pharma Services

Recently, the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) opened an investigation into a patient complaint of mold on paracetamol (acetaminophen) tablets (1). It discovered the product was shipped by sea from India to multiple companies in the UK at temperatures reaching up to 60 degrees Celsius. Labeling for paracetamol tablets typically states they should be kept below 30 degrees Celsius. In addition, MHRA discovered the humidity levels exceeded 80 percent during shipping, which is too high for the packaging that was used.
More info >>

 
Industry Events

12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

8-11 February 2021, Vienna, Austria

In continuation of the very successful scientific meetings in Budapest, Paris, Berlin, Florence, Geneva, Barcelona, Malta, Istanbul, Lisbon, Glasgow and Granada, the 12th PBP World will be held in Vienna from 8-11 Feb 2021. This every two year held conference has gained an ever increasing impact among the pharmaceutical scientists: With up to 1000 submitted abstracts and about 1300 participants it has become a well-established major meeting, attracting scientists from all over the world.
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement