spacer
home > ebr > winter 2003 > is resistance futile?
PUBLICATIONS
European Biopharmaceutical Review

Is Resistance Futile?

Resistance is futile, or so the battle cry of the new enemy of humans in Star Trek goes. However resistance is hardly futile in the case of the retrovirus HIV. To date, HIV has infected 42 million people worldwide. In 2002 there were five million new infections and three million people died as a result of HIV infection or its end result - acquired immune deficiency syndrome (AIDS). The latest figures suggest that one person worldwide is infected with HIV every 60 seconds and 70 per cent of the burden of the world's HIV epidemic is carried by sub-Saharan Africa.

Since HIV-1 was isolated in 1984 and the cause of AIDS discovered, the innovation in drug development has been unrelenting. HIV infects and destroys human CD4 receptor positive cells in human hosts. This destruction leads to a loss of the cellular immune response and thus a switch of the immune system from a TH1 response to a TH2 one. The destruction of CD4+ cells is caused by the assembly of new HIV virus particles and their final budding out of the infected cell.


Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

 You must be a member of the site to make a comment.
spacer
By Dr DC Herath, Senior Medical Advisor in HIV at Roche UK

Dr DC Herath completed his Medical Degree at St Mary's Hospital Medical School, London. During that time, Dr Herath also completed a BSc in Haematology, conducting a study into thrombophilic disorders in recurrent miscarriage women. Having graduated, he spent several years as SHO in the major specialities (Renal, Neurology, Cardiology, Gastroenterology, Respiratory and ID/HIV) all at St Mary's, and then worked as SpR in HIV at St Mary's before moving to Roche as Clinical Science Specialist on the TORO 2 study in February 2002. In June of this year, Dr Herath undertook the post of Senior Medical Advisor in HIV for the Roche UK affiliate, overseeing the whole HIV portfolio from a medical viewpoint. He is still a practising physician in HIV, with a patient list of 80 at St Mary's Hospital in London.

spacer
Dr DC Herath
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Arcis Biotechnology appointments Professor Steve Howell as Non-Executive Chairman

Daresbury, UK, 24 July 2019: Arcis Biotechnology (“Arcis”), the nucleic acid sample preparation solution provider, today announced it has appointed Professor Steve Howell as Non-Executive Chairman of its Board of Directors. Steve takes over the position from Paul Foulger, who was serving as Chairman on an interim basis on behalf of the Board.
More info >>

White Papers

Orthogonal Approaches for the Analysis of Protein Sequence

Ludger Ltd

One of the most important classes of biopharmaceuticals is monoclonal antibodies. They are expressed from living cells, and are consequently subject to complex biochemical pathways. Not all of these routes are fully understood, and many are sensitive to the subtlest of environmental changes. Changes such as these can affect the final biopharmaceutical sequence, structure and post-translational modifications, not to mention any changes that may occur during further purification. This often means that the final product from one batch may be different from the last in another batch. Each batch is a complicated mix of similar molecules, and analysis of the degree of batch-to-batch variation is therefore very important to the establishment of the drug's safety for medicinal use and patient administration.
More info >>

 
Industry Events

Clinical Trial Supply Europe

11-12 March 2020, Madrid, Spain

The 21st annual edition promises to grow on the success of 2019’s excellent conference which saw delegates from Europe’s largest pharmaceutical companies and biotech innovators come together to discuss, debate and unpack the latest trends in clinical supply chain innovation. 2020 will offer delegates the opportunity to address the growing need for agility within the supply chain in response to increasingly complex trial demands. With a stream dedicated to supply operations and another to innovative uses of technology in the supply chain, delegates will get the chance to gain practical take-aways that they can apply to their own studies.
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement