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| home > pmps > spring 2021 > how air casters benefit continuous manufacturing in chromatography |
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Pharmaceutical Manufacturing and Packing Sourcer
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The goal of continuous manufacturing in pharmaceutical production is to consistently reduce human error, enable more flexible drug tracking and tracing, and optimise production efficiency. Now, this trend has extended to chromatography, and for good reason. The FDA, the US equivalent of the EMA, has identified chromatography as the last component of the pharma manufacturing industry that needs perfecting in order to bring the real potential of continuous manufacturing full circle. With true continuous manufacturing practices, biomanufacturing can produce drugs and other bioproducts much faster, more reliably, and at lower cost. Johnson & Johnson, for example, switched to continuous manufacturing for its HIV medicine Prezista (darunavir) and reduced production time from about two weeks to just three days (1).
Chromatography equipment, however, cannot operate continuously without regularly cleaning, repacking, and frequent movement of columns. As experience has shown, traditional solutions, such as wheeled casters and tuggers do not lend themselves to continuous manufacturing processes. A better alternative is the integration of air caster technology, which increases the likelihood of seamless chromatography, improves potential for achieving EMA-approved cleanroom compliance, and fosters ergonomic goals to meet the needs of employee safety.
What Are Air Casters?
Originally developed for use in the aerospace industry, air casters are inflatable, doughnut-shaped bags that create a thin film of air capable of floating multi-ton loads. Once the bags have inflated, excess air escapes underneath and creates lift. This film of air, no thicker than a business card, reduces friction coefficient to around 1% so that air casters require only about one-tenth the force to move as wheeled casters.
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News and Press Releases |
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Humanigen Enters into Agreement with PCI Pharma Services as Part of Preparations for Commercialization in the United Kingdom
SHORT HILLS, NJ. June 16, 2022--(BUSINESS WIRE)-- Humanigen, Inc.
(Nasdaq: HGEN) (“Humanigen”), a late-stage clinical biopharmaceutical
company focused on preventing and treating an immune hyper-response
called ‘cytokine storm,’ today announced it entered into an agreement
with PCI Pharma Services (PCI), a leading integrated global contract
development manufacturing organization (CDMO), to provide importation,
release and commercialization services in the United Kingdom (UK) for
lenzilumab. Under the agreement, PCI will purchase lenzilumab for resale
and distribution in the event a Conditional Marketing Authorization is
received in the UK for use in patients hospitalized with COVID-19.
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White Papers |
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Considerations for Choosing the Right Wearable Drug Delivery System
West Pharmaceutical Services, Inc.
For patients with chronic conditions, the use of injectable biologic therapies is on the rise. Biologics, while providing considerable therapeutic benefit, can also present several challenges for both drug manufacturers and patients. In particular, many biologics are highly viscous and others require large doses to be injected slowly over time. This can make it difficult to deliver a consistent dose every time, potentially impacting medication adherence.
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Industry Events |
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Connect in Pharma
14-15 September 2022, Plaexpo, Geneva, Switzerland
The new event driving innovation for pharma and biopharma businesses,
Connect in Pharma will unite key players in Pharmaceutical and
Biopharmaceutical packaging and production in Geneva on 14 – 15
September 2022.
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