The AARDEX group has a decade of experience in providing the monitors, information technology and expertise for measuring, analysing and improving patient adherence to and persistence with prescribed or protocol-specified drugs in ambulatory pharmacotherapy. Technology and expert analysis optimally target intervention to improve adherence.

Anything that can be measured can be managed. AARDEX group has developed several generations of MEMS® (Medication Event Monitoring Systems). The comparison of the patient’s drug dosing history with the prescribed drug dosing regimen is the basis for the quantitative analysis of adherence and targeted intervention.

No two drugs will require the same solution – AARDEX group brings novel statistical methods for the analysis and interpretation of dosing history data and their ability to explain the medical and economic effects of variable adherence to and persistence with prescribed medicines. AARDEX group maintains a growing database of electronically compiled drug dosing histories, with currently over 20,000 patients in different fields of ambulatory pharmacotherapeutics, for time periods ranging between 30 and 1,400 days. This resource is unique in both size and scope.

Drugs don’t work in patients who do not take them. Analyses of our database have revealed major findings in ambulatory patients’ adherence. Patterns of deviation from prescribed dosing regimens vary widely across individual subjects, but are almost entirely skewed toward longer dosing intervals than prescribed, in other words underdosing, in every field of treatment. Delayed doses, forgotten doses, drug holidays (three or more consecutive days without drug intake) and early cessation of dosing are common features in ambulatory patients.

One of the major findings of our analyses is that the quality of regimen execution predicts the time to treatment discontinuation. In other words, the better a patient observes the prescribed dosing regimen, the longer his/her persistence.

This finding is one of the keystones of our medAmigo intervention programmes. MedAmigo programmes combine the technique of measurement guided medication management (MGMM), which is the only statistically proven tool for lengthening patients’ persistence with prescribed drug dosing regimens.