Experimental Toxicology Services (ETS) Nederland BV, based in Zutphen, the Netherlands, is a privately owned product development consultancy managed by Henk Tennekes, Ph.D.

ETS ensures high quality monitoring of outsourced toxicology studies in close collaboration with study sponsors, usually R&D departments of pharmaceutical and biotech companies.  ETS mediates between sponsor and the contract research organisation (CRO), objectively selects CROs that best suit the needs of the Sponsor, and gives the Sponsor insight in true costs.

Henk Tennekes is a highly experienced certified toxicologist and an expert in risk assessment. He has published authoritative papers in leading scientific journals:

• H. Tennekes, V.A. Gretton, and T. Stedeford (2009). Hazard and risk assessment of chemical carcinogenicity within a regulatory context. To be published in: Cancer Risk Assessment: Carcinogenesis from Biology to Standards Quantification, John Wiley and Sons, Hoboken, NJ07030-5774.
• H. Tennekes, C. Gembardt, M. Dammann and B. van Ravenzwaay (2004). The stability of historical control data for common neoplasms in laboratory rats: adrenal gland (medulla), mammary gland, liver, endocrine pancreas and pituitary gland Regulatory Toxicology and Pharmacology 40, 18-27
• H. Tennekes, W. Kaufmann, M. Dammann and B. van Ravenzwaay (2004). The stability of historical control data for common neoplasms in laboratory rats and the implications for carcinogenic risk assessment. Regulatory Toxicology and Pharmacology 40, 293-304
• H. Tennekes, B. van Ravenzwaay, and H. W. Kunz (1985). Quantitative aspects of enhanced liver tumour formation in CF-1 mice by dieldrin. Carcinogenesis 6, 1457-1462
• H. A. Tennekes, L. Edler, and H. W. Kunz (1982). Dose-response analysis of the enhancement of liver tumor formation in CF-1 mice by dieldrin. Carcinogenesis 3, 941-945
• H. A. Tennekes, A. S. Wright, K. M. Dix, and J. H. Koeman (1981). Effects of dieldrin, diet and bedding on enzyme function and tumor incidence in livers of male CF-1 mice. Cancer Research 41, 3615-3620

ETS services include:

• Custom design of R&D programmes,
• Contract research organisation (CRO) selection,
• Study design and protocol review of in vivo and in vitro studies (ADME, toxicology, and secondary pharmacology),
• Monitoring and follow-up of non-clinical studies,
• Pharmacokinetic (PK) and toxicology data analysis and reporting,
• Preparation of expert reports, PK and toxicology summaries,
• Contributions to Investigator’s Drug Brochures (IDB), Investigational New Drugs (IND), New Drug Applications (NDA), Dossiers According to Directive 91/414/EEC, Biocidal Product Directive 98/8/EC, etc.
• Preparation of manuscripts for scientific journals (ghostwriting),
• In-sourcing and staff training courses (upon consultation).

ETS has served leading companies in the chemical industry since 1992, including:

• Ciba Geigy Pharma AG
• Sandoz Pharma AG
• Sandoz Agro AG
• Novartis Crop Protection AG
• BASF SE
• Novartis Pharma AG
• Yamanouchi Europe B.V.
• Shell International B.V.
• Zeneca Agrochemicals Ltd
• Monsanto GmbH
• Solvay Pharmaceuticals B.V.
• Henkel KGaA
• UCB S.A.
• Makhteshim Ltd