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European Pharmaceutical Contractor
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Large pharmaceutical organisations are failing to meet their commitments in terms of shareholder return, and in 2002 an unprecedented number of its major players were forced to issue profit warnings, many for the first time in their history. This has been driven by a number of factors:
Deteriorating R&D productivity
Cost containment by health care providers
Shortening exclusivity periods for compounds in the marketplace
Impending patent expiries in the next few years
Increasing regulatory uncertainty and timelines
Sales force saturation
Of all of these, R&D productivity has perhaps become the most visible problem. Over the last three decades, investment in R&D has risen exponentially from $600 million in the US in 1970 to $24 billion in 1999, whilst the number of NCEs approved by the FDA has actually fallen.
Companies have responded to any pipeline paucity in a number of ways, including mergers, acquisitions, internal process re-engineering, organisational restructuring, partnering with external organisations and a variety of more tenuous methodologies. These have met with varying degrees of success but have not led to the changes the shareholders had been promised, and quite rightly expected.
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