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European Pharmaceutical Contractor

Clinical Trials in Asthma

Respiratory physicians are buzzing about the number of new asthma drugs being developed by a variety of pharmaceutical companies. This is good news for approximately 155 million people worldwide who are affected by the disease. The prevalence of asthma is increasing, generally thought to be associated with spreading urbanisation and exposure to respiratory toxins - including domestic mites, vehicle exhaust and passive smoking.

Asthma is caused by both host risk factors and environmental risk factors. Host factors include genetic predisposition, atopy, airway hyper-responsiveness, gender, race and ethnicity. Environmental factors which increase susceptibility include indoor and outdoor allergens, tobacco smoke, air pollution, respiratory infections - especially viral disease, family size, diet, drugs, obesity and family pets. Recently there has been much research into asthma but the balance between nature, nurture and the changing environment remains poorly understood. We have a long way to go, but there are the beginnings of new therapies for asthma which offer hope for the future.


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By Dr Alan Davies, Therapeutic Director for Kendle International Inc

Dr Alan Davies qualified at the London Hospital Medical College, obtaining an MB BS in 1975 and an MRCP in 1979. Dr Davies has more than 20 years' experience in drug and device development. He has worked as a University Lecturer in the Medical Schools of Adelaide in Australia, and Manchester and Bristol in the UK. He was awarded an MD in 1988 for his original work on microvascular disease and glycaemic control in children with insulin-dependant diabetes mellitus. Dr Davies joined Novo Laboratories in 1988 and became Head of Clinical Research for Fujisawa GmbH, Munich in the 1990s. Since 2000 he has been Therapeutic Director for Kendle International Inc, one of the world's largest contract research organisations.

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Dr Alan Davies
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Industry Events

4th Annual Patient Recruitment and Retention in Clinical Trials

13-15 October 2008, Amsterdam

Patient recruitment is now consuming thirty percent of clinical trial time - more time than any other clinical trial activity - and almost half of all trial delays result from patient recruitment problems. As the recruiting culture becomes more sophisticated and the forces affecting patient enrollment grow more numerous and complex, pharmaceutical companies are striving to discover new strategies to facilitate enrollment in clinical trials. With increasing industry pressure to develop, test and market greater numbers of new drugs faster, pharmaceutical companies need to perform clinical trials as quickly as possible. Inefficient patient recruitment processes is a formidable barrier to pharmaceutical companies' success in launching new products. Improving the patient recruitment process is imperative to avoid wasted investments and eliminate costly delays in bringing new drugs to market -- today and even more so in the not-so-distant future. Improved patient recruitment presents one of the largest opportunities for pharmaceutical companies to eliminate delays in clinical trials, thereby making it possible to reduce time to market.  With patent time limits and large overheads meaning that any delays in the development timeline can be disastrous, a good understanding of how to successfully recruit patients for trials is vital for any company looking to succeed.
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News and Press Releases

New PFA SonicLineŽ ultrasonic flowmeters

Flow measurement with ultrasound fast, precise, free from contamination         The new PFA SonicLineŽ ultrasonic flowmeters assure precise measurement and control of chemical consumption and management of chemical stocks with high reliability. SonicLineŽ is also ideally suited for accurate batch and dosing processes with high reproducibility.              
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