home > epc > spring 2013 > a methodological approach
European Pharmaceutical Contractor

A Methodological Approach

In his recent book, Thinking, Fast and Slow, Daniel Kahneman discusses how statisticians make intuitive judgements about experiments they are analysing. He and his late colleague Amos Tversky concluded that statisticians are not good with intuition. They found that they greatly exaggerate the likelihood that the results of an experiment will be successfully replicated, even with a small sample, and that they even gave very poor advice to a graduate student in their experiment, about the numbers of observations that she would have to collect to conduct her (fictitious) study. This work, which is reported in full in the book, was the starting point for Kahneman to begin the work with Tversky which eventually won him the Nobel Prize.

Statistics in Medicine is a weighty tome. Now in its third edition, it has been fully revised and would seem to provide an excellent pathway for people wishing to learn about statistical methods in medicine. The book covers many basic statistical techniques and provides a good starting point for further enquiry. It also gives an excellent piece of advice: budding statisticians should meet qualified statisticians and ask questions about their methodology and their experience. The book is careful to distinguish between observational studies and clinical trials (experimental studies) and offers wise advice that observational studies should make modest claims; advice which should be heeded by the modern media who trumpet the results of such studies on the front pages of our newspapers. This, of course, links back to the observations of Kahneman and Tversky regarding intuitive statisticians.

This work provides a thorough grounding in the statistical methodology that a budding statistician would wish to employ. It claims to cover 90 per cent of all statistical analyses that are likely to be encountered. Where a topic is not treated in great depth, for example Bayesian analysis, useful references are sited for further enquiry.

Many examples of statistical analyses are given in the book and these are taken from real medical studies, although some are edited better to illustrate the statistical method employed. The book is extensively referenced, contains many useful exercises for the reader to follow, and has a set of databases that can be used in following these exercises. The book was written to teach and provide reference on statistical methods for research workers in the medical sciences. It assumes little basic knowledge of mathematics and statistics, but requires an intelligent, alert and motivated student with ability in arithmetic. The only omissions that I have noted is a chapter dealing with adaptive clinical trials, which are now being increasingly adopted, and any mention of conjoint analysis, which is extensively used in social sciences and again being increasingly used in quasiobservational studies in medicine. As a primer in its chosen subject, the book has much to recommend it.

Statistics in Medicine by Robert H Riffenburgh is published by Academic Press. ISBN 978-0-12-384864-2

Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:

There are no comments in regards to this article.


Print this page
Send to a friend
Privacy statement
News and Press Releases

Sustainability, plastics and Brexit: Keynote speakers set to inspire at PPMA Total Show 2019

Experts from IKEA, the British Plastics Federation and The Sunday Times to create a forum for education, knowledge-sharing and debate
More info >>

White Papers

7 Common Myths about QP Training Debunked: A Guide for Senior Managers


The role of the Qualified Person (QP) in the pharmaceutical industry is mandated by law (Directive 2001/83/EC, Directive 2001/20/EC, UK SI 2012/1916, UK SI 2004/103). Every holder of a relevant Manufacturers Authorisation (human and veterinary) must have at least one QP; without one, no batch of medicinal product can be certified for release for sale.
More info >>

Industry Events



SAPHEX 2019 will be held on the 23rd-24th October at the Gallagher Convention Centre, Johannesburg, South Africa.
More info >>



©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement