|
 |
| home > epc > spring 2002 > peptide pharmaceuticals manufacturing - making fmoc solid phase synthesis the preferred route |
|
|
 PUBLICATIONS |
European Pharmaceutical Contractor
|
Peptide drugs account for worldwide sales of US$3.5 billion and are estimated to be growing at a rate of 10 to 15 per cent per annum. This currently represents about 5 per cent of the overall pharmaceutical market. Simply rolling this through takes sales to around US$5 billion by 2005. And the potential is steadily increasing. The human genome has now been mapped by private as well as public bodies. It was estimated prior to completion that the human genome would contain around 120,000 genes, calculated from the number of individual genes required to code the molecules of life. It transpires that there may only be as few as 26,000 to 30,000. This raises the prospect that not only must each gene code form more than one protein, but proteins may act together to give a new effect. The study of these interactions has given rise to a new technology - proteomics.
It is expected that the Human Genome Project, coupled with proteomics, will lead to large numbers of new peptide and protein drug candidates. Numerous companies are on the discovery trail and are utilising a whole range of technologies to exploit and map these molecules. This is likely to cause an explosion in the number of peptide and protein drugs moving into the clinic. Are we about to enter a golden era for biopharmaceuticals? Major Pharma seems to think so.
We are seeing a renewed interest from Major Pharma in these molecules as they partner with the biotech discoverers, providing the financing and skills needed to take them to market. In addition, the number of collaborations being signed with the basic science providers (genomics, proteomics and so on) is accelerating. With the discovery of mechanisms to generate more molecules, research at the back-end has also increased. For example, at the last count there were over 40 companies involved in solving just the issue of delivery. Some examples of these are:
|
Read full article >>
|
|
 |
|
| Rate this article |
You must be a member of the site to make a vote. |
|
Average rating: |
0 |
| | | | | |
|
|
 |
Industry Events |
 |
Small Scale Biomanufacturing – clinical trials, cell & gene therapies
18 September 2008, Clifton Pavilion, Bristol Zoo Gardens, Bristol
This one day conference, sponsored by bioProcessUK and organised by BioApproaches South West, will cover key, important topics relating to small scale GMP biomanufacturing.
More info >> |
|
 |
News and Press Releases |
 |
“PACK DIFFERENT” with EMBALLAGE 2008
“Business, Innovation, Outlook” are the watchwords for the 38th World Packaging Exhibition which opens in Paris from 17 to 21 November 2008. Fifteen months before the key packaging event of the end of 2008, EMBALLAGE displays its differences to offer you a new edition that is even more representative, international and rich in new features.
More info >> |
|
 |
