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European Pharmaceutical Contractor

Power over the People?

Dr Georg A Mathis of Appletree Ltd goes in search of the secret to successful pharmaceutical project management

According to Peter Drucker, “The project leader is like the conductor of a symphony, who does not possess all the competences needed to fulfil the needs of the audience, but is none the less in charge of fulfilling these needs.” Being commonly defined as a series of parallel and/or sequential activities designed to reach a pre-defined objective, with a defined start and end point, a project is allocated and makes use of a variety of resources, and requires extensive coordinative action.

A PROJECT IS NOT A PROJECT

In different contexts, projects may have very different features. Project management was created in the construction industry in the middle of the twentieth century by engineers who realised that a special competence was required to bring together at the right time and place the many parties contributing to a construction site. Project management was developed to perfection by the US National Aeronautics and Space Administration (NASA) in its drive to put man on the moon.

It is also widely used in the information technology environment and, last but not least, in the pharmaceutical industry. However, there is a significant difference between a pharmaceutical industry project and, say, a construction project.

While a construction project is normally run top down along the established lines of report and control (that is, the project responsibilities and the line leadership responsibilities overlap), a project in the pharmaceutical industry is usually organised in a matrix – along lines of report and control different from the established hierarchy (see Figure 1a and 1b).


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Georg A Mathis is a trained Doctor of Veterinary Medicine with a PhD in Pharmacology (both from the University of Zurich, Switzerland) and an MBA from the State University of New York at Albany. He acquired experience in clinical practice, basic research in cell biology and cellular metabolism, and clinical pharmacology. He spent the last 15 years in the pharmaceutical and healthcare industry, most of those in executive positions. Since 2002 he has been CEO of Appletree Ltd, a contract services organisation that specialises in ophthalmology, which he founded with two partners.
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Georg A Mathis
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4th Annual Patient Recruitment and Retention in Clinical Trials

13-15 October 2008, Amsterdam

Patient recruitment is now consuming thirty percent of clinical trial time - more time than any other clinical trial activity - and almost half of all trial delays result from patient recruitment problems. As the recruiting culture becomes more sophisticated and the forces affecting patient enrollment grow more numerous and complex, pharmaceutical companies are striving to discover new strategies to facilitate enrollment in clinical trials. With increasing industry pressure to develop, test and market greater numbers of new drugs faster, pharmaceutical companies need to perform clinical trials as quickly as possible. Inefficient patient recruitment processes is a formidable barrier to pharmaceutical companies' success in launching new products. Improving the patient recruitment process is imperative to avoid wasted investments and eliminate costly delays in bringing new drugs to market -- today and even more so in the not-so-distant future. Improved patient recruitment presents one of the largest opportunities for pharmaceutical companies to eliminate delays in clinical trials, thereby making it possible to reduce time to market.  With patent time limits and large overheads meaning that any delays in the development timeline can be disastrous, a good understanding of how to successfully recruit patients for trials is vital for any company looking to succeed.
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