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| home > ebr > Summer 2010 |
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 PUBLICATIONS |
European Biopharmaceutical Review |
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| Geographic ‘clusters’ of companies and institutions that share the same interests can prove to be a more fluid way of achieving desired targets when faced with global markets and competition, finds Christian Garbe at FIZ Frankfurt Biotechnology Innovation Center. |
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| The pharma business model is changing, requiring companies to achieve a higher base level in core competencies and to adapt to the more complex demands of current deals and transactions, explain Andrew Jones and Leo Gribben at Ernst & Young. |
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| In today’s world, pharmaceutical publicity offices must adapt to rapid media developments as they occur.Donna L LaVoie of LaVoie Group summarises strategic steps for integrated partner communications. |
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| Malcolm Young at e-Therapeutics plc and Alan Whitmore at Lumemed Ltd discuss how awareness of the potential advances in research is essential if businesses want to access truly up-to-date technologies, and avoid being left behind in the marketplace. |
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| Autoimmune diseases are responsible for a significant share of the European pharma market, and offer a considerable opportunity to those willing to innovate and meet regulatory standards, argues Suraj Ramanathan at GBI Research. |
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| Critical limb ischaemia and related conditions are facing a powerful weapon in the form of placentalderived mesenchymal stromal cells. William R Prather at Pluristem Therapeutics, Inc reports on the advances which are underway in this field. |
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Juliet A Ellis and Francesco Muntoni at University College, London review developments in current research in RNA therapy, and explain its importance in the treatment of rare genetically determined diseases, particularly those affecting the central nervous system and muscle groups.
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Repositioning offers a cost-effective shortcut in the drug discovery process, yet for a variety of reasons it is nowhere near as commonly employed as it should be, shows Raúl Insa at SOM Biotech through discussion of several key examples of successfully repositioned drugs.
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Protein aggregation can have a decisive part to play in the quality and stability of biopharmaceutical products, with nanoparticle tracking analysis giving manufacturers greater control over this factor, explain Bob Carr and Andrew Malloy at NanoSight Limited.
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Rohan A Thakur and Michael Koleto at Taylor Technology discuss mass spectrometry, providing a detailed view of its uses and advantages, and demonstrating its potential for fast pharmacokinetic and semi-quantitative analysis of metabolites.
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| Rasika Ramachandran at Frost & Sullivan points out the benefits of using stratified medicine in drug discovery trials, and highlights how biomarkers have a big part to play in their effective implementation. |
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| Eleanor Root and Patrick Kelleher of Bird & Bird outline the existing regulatory infrastructure of biotechnology patent, including European rules, and provide examples that highlight the key issues. |
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| Lee Caffin and Vandana Mamidanna at Think IP Strategy assert the necessity of research into the patent background surrounding any discovery or innovation programme, and advise on how to spot risky situations. |
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There is massive potential for transgenic plants to assist in the production of pharmaceutical proteins. Kathleen L Hefferon at Cornell Research Foundation explains how plant-derived products can be safer, more effective, and cheaper to produce.
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Biopharmaceutical manufacturing provides more than just cost-effectiveness; Eric S Langer at BioPlan Associates, Inc discusses the range of benefits it has to offer and covers some of the developments in this area in the last year.
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Christopher Stewart at MPI Research outlines recent progress in biologics and offers some insight into the effect this has had on small molecule development, encompassing current regulations along the way.
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Steeped in a history of medical innovation and discovery, Scotland continues to be a prime location for the biotech and biopharmaceutical industries, as Rhona Allison at Scottish Enterprise reports.
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Timur Bondaryev and Svitlana Ivasenko at Arzinger show how, despite suffering as a result of the recent economic slump, Ukraine is making progress in the biotechnology sector, with plenty of examples of growth to be seen.
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News and Press Releases |
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BRIM Biotechnology Receives FDA Agreement on Phase 3 Clinical Trial Design for BRM421, BRIM’s Lead Candidate for Dry Eye Disease, at End of Phase 2 Meeting
Taipei, Taiwan, 1st November 2022 / Sciad Newswire / BRIM Biotechnology, Inc. ("BRIM," TPEx 6885) is pleased to announce that it has received
agreement from the US Food and Drug Administration (FDA) on the Phase 3
clinical trial design for its lead candidate for Dry Eye Disease (DED),
BRM421, at the End of Phase 2 Meeting. BRIM will submit the Phase 3
study protocol to the FDA in Q4 2022.
More info >> |
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White Papers |
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Modifying MDI Canister Surfaces to Improve Drug Stability & Drug Delivery
Presspart Manufacturing Ltd
Hydrofluoroalkane (HFA)-based propellants are widely used in modern metered-dose inhalers (MDIs), due to their lack hazardous and environmentally-damaging effects. However, an HFA's active pharmaceutical ingredient can interact with the canister substrate, causing deposition of the drug to the canister walls, or interact with the solution, causing degradation and resulting in increased impurity levels. Over the past few years, a number of surface coatings have been developed that can be applied to MDI canisters and valve components, to protect the contents from deposition and degradation. More recently, plasma processes have been developed to modify and improve the surface energy performance of a MDI canister. This approach has a number of advantages to alternative coatings but requires careful optimisation to ensure the highest quality finish and MDI performance. Richard Turner, Business Development Director, Presspart Manufacturing Ltd, explains.
More info >> |
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