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European Biopharmaceutical Review

ebr
Summer 2012
   
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BioBusiness, Finance & Communication

Biobusiness

This Drug Went to Market

When establishing a market access strategy, early-stage biotechs should carefully consider market requirements and value-based pricing to demonstrate the best product value available, suggest Caroline Hall and David Alderson at GfK Bridgehead.

 
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Market Analysis

Hope on the Horizon?

Sri Rekha and Dina Rufo of GlobalData consider the current market for OCD therapeutics, and look at several developments that could open the field to new drug discoveries.

 
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BioResearch and Innovation

Biosimulation

Model Behaviour

Serge Bischoff of Rhenovia Pharma looks at how biosimulation can offer an effective means of modelling data on rare and orphan diseases, creating hope for new drug discoveries in complex and frequently challenging fields.

 
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Natural Products: Drug Discovery

Harnessing Nature’s Orphan Ligands

New opportunities are emerging to reincorporate natural products into mainstream drug discovery. Developments in marine microbiology offering a promising starting point, argues Guy T Carter of Carter-Bernan Consulting, LLC.

 
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Novel Therapeutics

Beating a New Path

The adverse side effects of levodopa therapy represent a serious problem to late-stage Parkinson’s disease treatment. Stephan Schann of Domain Therapeutics discusses research into candidates that could alleviate these symptoms.

 
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Research Models

The Right Approach

Many successful drugs act on membrane proteins to inhibit signalling processes. Gunnar von Heijne of Stockholm University suggests that Big Pharma can leverage cutting edge research in this area by collaborating with academic research centres.

 
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Discovery Technology

Stem Cell Research

In the Fast Track

Uma Lakshmipathy and Magnus Persmark of Life Technologies explore the recent developments in stem cell tracking and labelling, and how the process can assist in the fi elds of cell therapeutics and tissue engineering.

 
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Lab-on-a-Chip

Accelerated Research

Manufacturing breakthroughs in polymer-based smart chips have made the promise of lab-on-a-chip technology an affordable reality. Chris Mauracher of Sony DADC explains how drug discovery can benefit from these developments.

 
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Biomarker Discovery

Autopilot

When seeking to characterise autoantibodies for use in diagnostic biomarker panels, protein microarrays can offer a high-throughput, reliable alternative to traditional ELISA platforms, argue Michael McAndrew, Colin Wheeler and John Anson of Oxford Gene Technology.

 
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Immunoassays

Small is Beautiful

Karolina Österlund at Gyros AB investigates recent developments in microfluidic immunoassay technology, and calculates the cost- and time-saving benefits this can bring researchers from the lab to the clinic.

 
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Glycosylation

Right Reactions

With the rise of biosimilars, it is increasingly important for researchers to efficiently determine oligosaccharide structures. David Neville of Reading Scientific Services Ltd explores technological advances in this field, and suggests that a combination of HPLC, mass spectrometry and enzyme digests are needed.

 
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BioDevelopment and Regulatory

Pharmacovigilance

All Eyes on Europe

Sonia Araujo of Medidata Solutions offers a snapshot of European regulatory changes to pharmacovigilance, with an emphasis on patient participation and addressing the challenges of reporting adverse drug reactions.

 
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Model-Based Drug Development

A Safe Bet?

Joachim Grevel at BAST Inc Limited and Marc Lavielle at INRIA Saclay present model-based approaches to drug development that can help reduce risk and increase clinical success.

 
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BioFormulation and Manufacturing

Biomanufacturing

Rapid Response Unit

When testing for microbial contamination in pharmaceutical production processes, a combined approach using both membrane filtration and fluorescence-based staining offers quick, robust results, as Renaud Chollet and Yves Courties of Merck Millipore SAS demonstrate.

 
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INDUSTRY DYNAMICS

In Brief

Decade of Biologics

Kellie Medeiros and Emile Bellott, independent pharmaceutical consultants, outline regulatory changes set to rock the biosimilars market.

 
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News and Press Releases

Airnov laser-marked desiccant canisters reduced risk of contamination by eliminating print or paper labels

• Laser marking produces clean, readable, permanent marking • Enables product and warning labeling without paper, ink or glue • Reduces risk of contamination of packaged pharmaceuticals and nutraceuticals
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White Papers

Delivering Fit For Purpose Biomanufacturing CHO Cell Lines

Fujifilm Diosynth Biotechnologies

The challenge during mammalian cell line development is to identify and isolate stable, high expressing cell lines producing product with the appropriate critical product quality attributes rapidly, reproducibly and with relative ease. Obtaining a host cell line that inherently exhibits desirable biomanufacturing attributes can therefore have a significantly positive effect on the identification of recombinant cell lines with desired traits during cell line development screens. In this study, we demonstrate that it is possible to exploit intrinsic heterogeneity within host cell populations and identify host cell lines which are more “fit for purpose”.
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Industry Events

CPhI Festival of Pharma

5-16 October 2020, Virtual

A virtual gathering for the pharmaceutical industry, the CPhI Festival of Pharma has been created to fill the gap left by in-person events at a time when travel and gatherings are off the cards.
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