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European Biopharmaceutical Review

ebr
Winter 2015

   
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Editorís Letter

In light of the Ebola outbreak, Deborah OíNeil reminds us just what our industry is capable of, as well as reflecting on a number of this editionís features.
 
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BioResearch and Innovation
Human Airway Epithelium

Hold Your Breath


Air-liquid interface culture models can provide a powerful platform in preclinical drug development for various respiratory diseases. Samuel Constant, Song Huang and Ludovic Wiszniewski at Epithelix and Christophe Mas at OncoTheis explore further.
 
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Discovery Technology
Fluorinated Pharmaceuticals

Synthesis and Opportunity


As fluorinated active pharmaceutical ingredients continue to be introduced into the marketplace, Graham Sandford at Durham University and Cormac Murphy at University College Dublin examine the technology.
 
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BioDiscovery
Molecular Biomarkers

Mental Change


Efforts in the field of mental illness could lead to novel therapeutic targets and the individualisation of patient strategies. Paul C Guest at Cambridge University reflects on how considering schizophrenia as a whole body disease may result in better treatment approaches.
 
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Biodevelopment and Manufacturing
Biomanufacturing Strategies

Keep it Flexible


Accinovís Sylvain Peyrache and Agnes Nagy contemplate the effect biologics are having on the biopharmaceutical industry. With the recent progression of technology, new solutions are allowing companies to implement biomanufacturing strategies far more easily according to regulation requirements and project timelines.
 
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Cell-Based Therapeutics

Heading For Market


Stefanos Theoharis
from apceth GmbH maintains that it is imperative to keep in mind the various end-goals when developing cell-based therapeutics. This will position the final product well in the marketplace of tomorrow, and deliver real benefit to patients in need.
 
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Biopharmaceutical Manufacturing

Synthetic Biology


Dominik Schelshorn, Sanda Ljubicic, Imre Berger and Daniel Fitzgerald of Geneva Biotech contemplate the new era of synthetic biology, and how the rapid advance of tools and technologies is changing the way we produce biopharmaceuticals.
 
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THERAPEUTICS FOCUS - VACCINES AND INFECTIOUS DISEASES
Case Study: Schistosomiasis

Positive Action


Schistosomiasis is one of the most prevalent Ė yet often neglected Ė parasitic diseases. Elly Kourany-Lefoll, Jennifer Keiser and Remco de Vrueh at the Pediatric Praziquantel Consortium explain how a recent collaboration hopes to formulate readily administrable treatments.


 
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Q&A: Vaccine Insight

Developing Immunity


Frost & Sullivanís Aish Vivekanandan guides EBR through the hurdles of vaccine development and the impact of Ebola, before discussing what we can expect from the next decade of research.
 
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CANCER FOCUS
Active Immunotherapy

Fighting Fit


Research has shown the potential for targeted immunotherapy in non-infectious diseases, specifi cally in the prevention and management of non-small-cell lung cancer. Biovenís Erik DíHondt and Pangaea Biotechís Jordi Bertran-Alamillo and Jordi Codony-Servat comment on recent clinical trial results.
 
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Radioimmunotherapy

Alpha, Better


Treating cancer is not a one-size-fits-all proposition. Kaushik Dave and Dragan Cicic from Actinium Pharmaceuticals Inc run through the latest developments in radioimmunotherapy and the promising effects of alpha-emitters in reducing cancerous cells.
 
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Oncology Studies

Put to the Test


SMS-oncologyís Lindy Bosch and Raymond Hoffmans look at the components typically comprising a Phase 1 oncology study, describing characteristics such as sponsor types, drugs used, dose levels and patient stratification, as well as overall trial objectives.
 
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REVIEWS AND PREVIEWS
Event Review: Crystallography

Crystal Clear


Following on from 2014 Ė the Year of Crystallography ĖEBRís Emma Naks reviews photographer Max Alexanderís exhibition, Illuminating Atoms, which captured crystallography experiments in action, as well as displaying portraits of modern day crystallographers
 
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INDUSTRY DYNAMICS
Funding Models

Destination Europe


Poul SÝrensen and Emil Pot of European Biopharmaceutical Enterprises comment on Europeís sluggish R&D output, and recommend mobilising investment to encourage innovative entrepreneurship as a means of boosting economic growth.
 
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In Brief

Crouching Tiger


Emile Bellott casts his mind east and asks: will China have multinational pharma companies of its own? And how will they compare to those in Europe and America?
 
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INTELLECTUAL PROPERTY AND TECH-TRANSFER
Intellectual Property Act

Right of Way


Jasnoop Cheema at Greenaway Scott assesses the UKís Intellectual Property Act, outlining how the latest changes hope to simplify the current patenting process and encourage growth in the life sciences sector.
 
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Edited by
Dr Deborah O'Neil,
Chief Executive and Scientific Officer,
NovaBiotics Ltd
Published quarterly in
January, April,
July and October

News and Press Releases

YHEC announces the promotions of Michelle Jenks and Rachael McCool to the role Project Director

YHEC is pleased to announce the promotions of Michelle Jenks from the Economic Modelling team and Rachael McCool from the Systematic Reviewing team to the role Project Director. Michelle has a Masterís degree (MSc) in health economics from the University of York and has conducted economic evaluations and systematic reviews for both public and private sector clients. Michelle is the lead modeller in YHECís role as an External Assessment Centre for NICE and has also led on a range of economic evaluations conducted for clients within industry, such as cost-utility models and budget impact models. She often leads the development of early economic analyses to inform clinical trial design and pricing strategy.
More info >>

White Papers

Running Better Trials Taking an Intelligent Monitoring Approach

Bioclinica

When it comes to implementing a risk-based monitoring program, it is not just about reducing monitoring visits and doing less Source Document Verification (SDV). Itís about bringing together your people, a solid process, and the right technology to run a better trial. Success with risk-based monitoring requires the ability to make sense of the thousands, if not millions, of data points captured by multiple disparate sources in a clinical trial. With the sheer volume of data generated on a daily basis comes complexity. How does one make sense of it all? Information overload burdens even the most experienced study teams who struggle to understand which data matters most and what it means.
More info >>

Industry Events

PREP 2018: 31st International Symposium and Exhibit on Preparative and Process Chromatography

8-11 July 2018, Hyatt Regency in the Baltimore Inner Harbor, MD, USA

The PREP series of symposia is the most recognized international conference devoted to advances in separation technologies in the field of preparative and process chromatography. Join us for a dynamic and innovative program where experts from around the world will address the latest developments and hottest topics in preparative and process chromatography.
More info >>

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