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European Biopharmaceutical Review

ebr
Winter 2015

   
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Editor’s Letter

In light of the Ebola outbreak, Deborah O’Neil reminds us just what our industry is capable of, as well as reflecting on a number of this edition’s features.
 
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BioResearch and Innovation
Human Airway Epithelium

Hold Your Breath


Air-liquid interface culture models can provide a powerful platform in preclinical drug development for various respiratory diseases. Samuel Constant, Song Huang and Ludovic Wiszniewski at Epithelix and Christophe Mas at OncoTheis explore further.
 
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Discovery Technology
Fluorinated Pharmaceuticals

Synthesis and Opportunity


As fluorinated active pharmaceutical ingredients continue to be introduced into the marketplace, Graham Sandford at Durham University and Cormac Murphy at University College Dublin examine the technology.
 
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BioDiscovery
Molecular Biomarkers

Mental Change


Efforts in the field of mental illness could lead to novel therapeutic targets and the individualisation of patient strategies. Paul C Guest at Cambridge University reflects on how considering schizophrenia as a whole body disease may result in better treatment approaches.
 
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Biodevelopment and Manufacturing
Biomanufacturing Strategies

Keep it Flexible


Accinov’s Sylvain Peyrache and Agnes Nagy contemplate the effect biologics are having on the biopharmaceutical industry. With the recent progression of technology, new solutions are allowing companies to implement biomanufacturing strategies far more easily according to regulation requirements and project timelines.
 
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Cell-Based Therapeutics

Heading For Market


Stefanos Theoharis
from apceth GmbH maintains that it is imperative to keep in mind the various end-goals when developing cell-based therapeutics. This will position the final product well in the marketplace of tomorrow, and deliver real benefit to patients in need.
 
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Biopharmaceutical Manufacturing

Synthetic Biology


Dominik Schelshorn, Sanda Ljubicic, Imre Berger and Daniel Fitzgerald of Geneva Biotech contemplate the new era of synthetic biology, and how the rapid advance of tools and technologies is changing the way we produce biopharmaceuticals.
 
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THERAPEUTICS FOCUS - VACCINES AND INFECTIOUS DISEASES
Case Study: Schistosomiasis

Positive Action


Schistosomiasis is one of the most prevalent – yet often neglected – parasitic diseases. Elly Kourany-Lefoll, Jennifer Keiser and Remco de Vrueh at the Pediatric Praziquantel Consortium explain how a recent collaboration hopes to formulate readily administrable treatments.


 
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Q&A: Vaccine Insight

Developing Immunity


Frost & Sullivan’s Aish Vivekanandan guides EBR through the hurdles of vaccine development and the impact of Ebola, before discussing what we can expect from the next decade of research.
 
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CANCER FOCUS
Active Immunotherapy

Fighting Fit


Research has shown the potential for targeted immunotherapy in non-infectious diseases, specifi cally in the prevention and management of non-small-cell lung cancer. Bioven’s Erik D’Hondt and Pangaea Biotech’s Jordi Bertran-Alamillo and Jordi Codony-Servat comment on recent clinical trial results.
 
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Radioimmunotherapy

Alpha, Better


Treating cancer is not a one-size-fits-all proposition. Kaushik Dave and Dragan Cicic from Actinium Pharmaceuticals Inc run through the latest developments in radioimmunotherapy and the promising effects of alpha-emitters in reducing cancerous cells.
 
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Oncology Studies

Put to the Test


SMS-oncology’s Lindy Bosch and Raymond Hoffmans look at the components typically comprising a Phase 1 oncology study, describing characteristics such as sponsor types, drugs used, dose levels and patient stratification, as well as overall trial objectives.
 
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REVIEWS AND PREVIEWS
Event Review: Crystallography

Crystal Clear


Following on from 2014 – the Year of Crystallography –EBR’s Emma Naks reviews photographer Max Alexander’s exhibition, Illuminating Atoms, which captured crystallography experiments in action, as well as displaying portraits of modern day crystallographers
 
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INDUSTRY DYNAMICS
Funding Models

Destination Europe


Poul Sørensen and Emil Pot of European Biopharmaceutical Enterprises comment on Europe’s sluggish R&D output, and recommend mobilising investment to encourage innovative entrepreneurship as a means of boosting economic growth.
 
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In Brief

Crouching Tiger


Emile Bellott casts his mind east and asks: will China have multinational pharma companies of its own? And how will they compare to those in Europe and America?
 
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INTELLECTUAL PROPERTY AND TECH-TRANSFER
Intellectual Property Act

Right of Way


Jasnoop Cheema at Greenaway Scott assesses the UK’s Intellectual Property Act, outlining how the latest changes hope to simplify the current patenting process and encourage growth in the life sciences sector.
 
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Edited by
Dr Deborah O'Neil,
Chief Executive and Scientific Officer,
NovaBiotics Ltd
Published quarterly in
January, April,
July, and October

News and Press Releases

Charles River Laboratories Continues Commitment to Oncology Drug Discovery

Charles River Laboratories International, Inc. (NYSE: CRL) today announced new additions to the Tumor Model Compendium. Charles River’s Compendium provides access to a comprehensive collection of well-established tumor models for early-stage oncology research.
More info >>

White Papers

Mouse Models for Evaluation of Vaccines and Therapeutics Against Staphylococcal Infections

IBT Bioservices

Introduction Staphylococcus aureus (SA) is a ubiquitous, formidable Gram-positive pathogen associated with skin and soft tissue, as well as lifethreatening systemic infections. SA is a leading cause of hospital- and community-associated infections worldwide, affecting humans and animals. The wide range of pathologies reflects the diverse abilities of this microbe to escape the innate and adaptive immune response using virulence factors. Since its first emergence in the 1960s methicillin-resistant SA (MRSA) has become endemic in hospitals and healthcare settings worldwide. In the 1990s, community associated MRSA strains (CA-MRSA) emerged, and are spreading worldwide posing a major global challenge.
More info >>

Industry Events

Biotech Showcase™ 2019

7-9 January 2019, Hilton San Francisco Union Square

Biotech Showcase™ is an investor and networking conference devoted to providing private and small- and mid-cap biotechnology companies an opportunity to present to and meet with investors and biopharmaceutical executives during the course of one of the largest annual healthcare conferences that attracts investors and biopharmaceutical executives from around the world.
More info >>

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