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European Biopharmaceutical Review

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Summer 2016

   
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Editor’s Letter

EBR’s Editor Deborah O’Neil introduces July’s edition by highlighting the speed at which pharma is moving towards an age of biologics, while discussing the emerging possibility of earlier diagnosis for all patients.
 
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BioResearch and Innovation
Dementia Spotlight

How to Get a Pre-Competitive Edge


Rodrigo Barnes
at Aridhia discusses the possibility of unlocking the secrets of dementia to reduce its effect. With the costs of the disease – both economic and personal – on the rise, the time is right for a more collaborative approach to curing it.
 
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Liquid Biopsies

Translating Research into Reality: Part 1


As DNA sequencing looks increasingly towards the use of liquid biopsies, the industry moves ever-closer to developing personalised treatment for all patients. Paul Elvin at Aptus Clinical explains the need to target specific mutations, and the effect that new ctDNA analysis may have on patients and developers alike.
 
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BioDiscovery
Biomarkers and Diagnostics

The Secrets in our Cells


Diamond Light Source’s Mary Cruse
sheds light upon recent work undertaken in cancer research, and the prospect of tailoring treatment to the genetic codes of any given patient – stating that perhaps the successful cure lies in each individual’s chemistry.
 
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INDUSTRY DYNAMICS
Comment: Shipment Conditions

How Strong is a Peptide Bond?


Have you ever wondered how much you could save on your logistics costs? According to Dr Henk J Bak at Eurosequence, there is a simple solution: bidding farewell to outdated methods and adopting more relevant shipping procedures.
 
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In Brief

Less is More


Governments, payers and patients alike are all calling for businesses worldwide to “do more with less”. Emile Bellott looks at the challenges we face as demands placed on the healthcare system threaten to intensify.
 
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BUSINESS STRATEGY
Content Management Software

Curse of the Patchwork Monster


The transformation of the life sciences landscape due to the digital revolution has created a stronger, quicker supply chain process. However, John Chinnici at Veeva Systems explains that despite its benefits, paper-based processes are still used by many companies. This can be combatted by implementing a fully digitalised supply chain.
 
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eHealth Revolution

From the Outside


Innovation from external sources has the potential to revolutionise the biopharma industry. Dr Ulrica Sehlstedt, Nils Bohlin, Fredrik de Maré andDr Richard Beetz at Arthur D. Little suggest that by embracing the digital, a positive change could be created for patient care, even if it means advances in other areas lose pace.

 
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RESEARCH AND DEVELOPMENT
Q&A: Idiopathic Pulmonary Fibrosis

Breathing Easy


In our latest Q&A, Dr Marilyn Glassberg enlightens EBR on everything from the main themes raised at ATS 2016 to her recent research, before revealing her biggest lesson in life.
 
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BIOIMAGING
Two-Photon Microscopy

The Next Step


A plethora of options have emerged to improve imaging capabilities for microscopists. Laser Quantum’s Andrew Wells explains the change in the priorities of manufacturers of laser equipment, and discusses the benefits of using ultra-fast lasers.
 
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CELL-BASED RESEARCH
Cell Disruption

Under Pressure


Technology that performs mechanical lysis and homogenisation of cells are often sold on the basis of the pressure they are able to reach. Recent research undertaken by Dr Matthew Lougher of Constant Systems, however, demonstrates that the success of mechanical cell disruptions depends on much more than pressure.
 
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Cell Culture Development

Up to Speed


Research shows that reducing the development time and costs associated with cell culture processes can be achieved by instigating high-throughput methods. Shahid Rameez and Abhinav A Shukla at KBI Biopharma discuss what this means for progress in novel biotherapeutics and their use in clinical trials.
 
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THERAPEUTIC DEVELOPMENT
Biosimilar Manufacturing

Gaining Ground


ProductLife Group’s Barbara Testa highlights the fact that the biosimilar sector is wrought with challenges regarding patient satisfaction and understanding – she explains that biosimilar popularity continues to rise, but physicians remain tentative.
 
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Genetic Disorder Therapeutics

Two Pillars of Fledgling RNA Medicine


It is becoming progressively difficult to find efficient, predictable and safe intracellular delivery strategies for curing genetic disorders. With the hope that a fuller understanding of RNA therapies will accelerate the process, Max Ryadnov at the National Physical Laboratory outlines the two main obstacles facing researchers and developers.
 
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Developments in Biosimilars

Winning the Race


The biosimilar testing process is complex, but it is becoming increasingly possible to employ a successful development programme. Dr Jon S Kauffman, Dr Weihong Wang and Dr Frederic Girard at Eurofins explore the feasibility of implementing these methods across the biopharma sector.
 
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Edited by
Dr Deborah O'Neil,
Chief Executive and Scientific Officer,
NovaBiotics Ltd
Published quarterly in
January, April,
July and October

News and Press Releases

Navigating the new Clinical Trial Regulation with DIA

For those stakeholders involved with clinical trials in Europe, the new Clinical Trial Regulation to be introduced in 2019 will have a dramatic impact. The aim of the change in regulation is to increase the efficiency of all trials in Europe, as well as promoting research while avoiding the duplication of clinical trials
More info >>

White Papers

pAVEway™ expression system for the efficient expression of therapeutic proteins

Fujifilm Diosynth Biotechnologies

One of the major bottlenecks in the production of biopharmaceuticals is the efficient expression of therapeutic proteins in microbial or mammalian cells. The Escherichia coli pAVEway™ expression system described here has been developed to ensure high product titres and efficient scale up to GMP manufacture, whilst minimising many common issues seen in other expression systems, such as ‘leaky’ expression (expression of recombinant protein in the absence of inducer).
More info >>

Industry Events

10th Annual Pre-Filled Syringes Europe 2018

17-18 January 2018, Copthorne Tara Hotel, Kensington, London UK

Join the calendar event highlight for the medical device industry at Europe's leading 10th annual conference and exhibition on Pre-Filled Syringes when it returns to Central London on 17th and 18th January 2018. Pre-Filled Syringes Europe will once again provide a perfect platform to discuss new advancements and showcase the latest innovations to keep you at the forefront of a dynamic and booming market.
More info >>

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