spacer
home > ebr > winter 2018 > cell-ebration
PUBLICATIONS
European Biopharmaceutical Review

Cell-ebration

Ever since scientists learned how to culture cells and tissue outside a living organism (in vitro) the method has served as an excellent, highly controlled experimental platform that has helped them understand the basics of cellular physiology: how cells function and respond to different stimuli. The era of ‘cell culturing’ started in the late 19th century with the development of the ‘Ringer solution’ – named after the British physiologist Sydney Ringer – and was further established by a number of pioneering publications by Ross Granville Harrison in the early 20th century (1-4).

With the discovery of how cells in culture can be multiplied and with the establishment of the first human-derived cell line (the ‘HeLa’ cells), a new avenue of research opened up for cell biologists, together with the foundation of work leading to fundamental knowledge about cellular behaviour.

However, although in vitro systems have been important during the last hundred years, there is an acceptance and mass of evidence that traditional two-dimensional (2D) in vitro systems – ie cells grown at the bottom of a glass flask – poorly reflect the complexity of the in vivo process. In the in vitro environment, tissue-specific architecture, mechanical and biochemical cues and cell-cell communications are absent (see Table 1), resulting in transitional issues within pharmaceutical research when going from in vitro-based models to animal models, ie ‘from bench to bedside’ (5).

Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
Professor Fredrik Johansson has an MSc in biophysics and a PhD in zoological cell biology. His research is focused on physical cues in interfaces between cells/tissue and artificial nanostructures. Frederik’s main body of publications describe how neurons in general and their cell extensions, in particular the axons, are affected by small structures. The nanostructures he has worked with are nanoimprinted polymer patterns, porous silicon and electrospun fibers, among others. Research into electrospinning also led to the formation of an electrospinning company Cellevate AB, of which Frederik is one of the cofounders. He is now an Associate Professor at Lund University, Sweden.

Maximilian Ottosson is one of the co-founders and the current Chief Executive Officer of Cellevate, a Swedish company working with the production and commercialisation of nanofibrous materials for life sciences applications such as tissue engineering and 3D cell culture. The company has so far successfully launched a product line for 3D cell culture based on fiber materials. Maximilian has an MSc in engineering, engineering nanoscience, with a specialisation in nano-biomedicine and biophysics from Lund University, Sweden.

spacer
Professor Fredrik Johansson
spacer
spacer
spacer
Maximilian Ottosson
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Countdown to the UK’s leading production line event begins

In light of Nick Peters’, author of the Annual Manufacturing report 2018, comment that “UK manufacturing has come a long way in recent years, as we have seen from their stellar performance in 2017,” it’s no surprise that the PPMA Show is gearing up for its biggest show to date when it returns to the NEC, Birmingham, between 25-27 September 2018.
More info >>

White Papers

Blockbuster Drugs Need Blockbuster Components

West Pharmaceutical Services, Inc.

Many of the world’s blockbuster drugs are now delivered via a prefilled syringe system or auto-injector. To ensure patient safety, pharmaceutical manufacturers need high-quality components that feature reduced particulates and ensure consistency of delivery while fitting the changing needs of higher-volume delivery systems.
More info >>

 
Industry Events

ACHEMA 2018

11-15 June 2018, Messe Frankfurt GmbH

ACHEMA is the world forum for the process industries, but also an integral part of the trade show calendar of companies specializing in pharma packaging. Every three years 3,800 exhibitors and 170,000 visitors gather in Frankfurt/Main, Germany for the trade show that features everything you need to furnish a chemical or pharma production plant.
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement