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European Biopharmaceutical Review

Training Day

As opposed to traditional pharmaceutical products, biopharmaceuticals are complex high-molecular-weight items of biological origin derived from living organisms, cells, animals or plants. Market predictions strongly suggest that sales of biopharmaceutical products will continue to increase year-on-year, with the market being driven primarily by further increases in sales of recombinant monoclonal antibodies (mAbs) that have proven to be successful therapies for a large number of disease states.

However, the focus on advanced therapy medicinal products is increasing, with some manufacturers looking to diversify into gene therapies, cell therapies and tissue engineering as strategies for pipeline development. By 2020, biopharma sales are estimated to contribute at least 50% of total biopharma and pharma revenues, with the former contributing 80% of product candidates in pipelines (1).

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Dr John Milne is currently Director of training at the National Institute for Bioprocessing Research and Training. He has been employed in the biopharma industry for 20 years and has performed in a series of roles, including process development, optimisation, scale-up and GMP manufacture of therapeutic proteins and mAbs in regulated facilities. John received his PhD in molecular enzymology from the Department of Biochemistry at University College Dublin.
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