spacer
home > ebr > spring 2018 > getting ahead
PUBLICATIONS
European Biopharmaceutical Review

Getting Ahead

Migraine is not a new or a rare disease: references to migrainelike conditions can be found as far back as Ancient Egypt, and it has been recognised by the WHO as one of the top 10 causes of years lost to disability worldwide (1-2). Despite this, migraine patients in need of a preventive option are likely to be prescribed a medication that has been developed for another condition such as epilepsy or depression, rather than something that was designed with migraine in mind. However, there is hope that this will soon change.

Pathophysiology of Migraine

The understanding of the pathophysiology of migraine has advanced hugely over the past two decades. While in the past theories of migraine focused on the vascular system, research has moved away from this towards a neuronal theory of migraine (3). However, the role of blood vessels and vasodilation is still not entirely understood.

Migraine is a complex neurological disease of the central nervous system (CNS), with several structures and brain areas implicated in its genesis. A key focus area has been the trigeminovascular system. This has connections with other key brain areas with axons reaching as far as the meninges. Activation of this system is thought to be a crucial step in a chain of events leading to migraine pain.

Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
Professor Dr Uwe Reuter is a neurologist and partner in the headache programme at Charité Universitätsmedizin, Berlin. After finishing his residency training in Berlin, he went to Harvard Medical School for a post-doctorate fellowship as a scholar for three years. During his time in Boston, Uwe focused on basic research in primary headaches and migraine aura and published several peer-reviewed publications in high impact journals. Ever since, he has had a strong interest in basic and clinical headache research. Uwe is a member of several national and international headache organisations and currently serves as board member of the European Headache Federation.
spacer
Professor Dr Uwe Reuter
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

MedPharm’s CSO and University of Reading Professor co-author new book on dermal formulation development

MedPharm’s Chief Scientific Officer and Co-Founder, Professor Marc Brown and University of Reading’s Professor Adrian Williams have co-authored the new book: ‘The Art and Science of Dermal Formulation Development”. It is the latest addition to ‘Drugs and the Pharmaceutical Sciences’, a series of textbooks and monographs published by CRC Press.
More info >>

White Papers

New Temperature Profiles from a Global Study

Laminar Medica

Recently there has been an influx of temperature mapping studies to collect sufficient ambient data to develop temperature profiles.  Solid temperature profiles on specific shipping routes are required to ensure streamlined packaging and robust lane qualification. The most reliable method to develop temperature profiles is to capture the actual reading from shipments, as well as using the historical and meteorological data to increase the confidence level.
More info >>

 
Industry Events

DIA 2019 Global Annual Meeting

23-27 June 2019, San Diego Convention Center

DIA 2019 is more than just a meeting: it’s where brilliant minds come together to create solutions. Thousands of global innovators will convene to engage in discussions on today’s hottest topics in the life sciences field, propose ways to combat daily challenges, and network to create lasting connections.
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement