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European Biopharmaceutical Review
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The first documented administration of insulin as an intervention
in diabetes was in 1922. A relatively crude extract from bovine pancreas
was injected into a 14-year-old boy in Toronto, and, although the first
injection was not entirely without complications, this intervention
ultimately saved his life. The subsequent impact of this discovery on
the lives of countless patients and our industry has been, to say the
least, transformational. Fast forward a century to 2022, and the
biosimilars of biopharmaceutically manufactured, synthetic insulins will
likely be mainstay therapies for diabetes, as Syneos Health's Rafal
Kokolus, Dr Doug Niven, and Rohit Sood discuss how the illness joins the
list of conditions for which all stakeholders are transitioning towards
biosimilar adoption.
If the rapidly expanding and often complex biosimilars universe is
not quite fully in focus for you yet, then articles in the summer 2018
edition of EBR will provide excellent overviews of the state-of-
the-art in defining by sequence (Dr Richard Easton and Dr Andrew Reason
at BioPharmaSpec) and protecting via optimal patent and commercial
strategies for these high-value ‘affordable’ biological therapeutics,
distinct in sequence and synthesis, yet ‘highly similar’ in efficacy and
safety to first generation proprietary forms of which they are
effectively ‘functional generics’ (Boult Wade Tennant’s Jennifer
O’Farrell, and Finnegans’ Sanya Sukduang and Thomas J Sullivan).
The first ever biosimilar drug product approval (by the EMA in
2006) was for a hormone therapy, omnitrope (somatropin), although the
first biosimilar insulin hormone was only approved as recently as 2014.
Antibody biosimilars, ‘adopted’ by the EMA and FDA more recently, have
made much more ‘noise’, arguably because of the premium priced
proprietary market pioneers they can replace. Three articles in this
edition of EBR focus on antibodies as the targeting component of
antibody-drug conjugates (ADCs) in cancer therapy (the team from Aptamer
Group, and Dr Neil Butt from IONTAS). ADCs are an increasingly
important drug class in oncology, evidenced by the fact that, according
to Professor Andreas Pahl from Heidelberg Pharma, more than 70 are now
in clinical trials.
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News and Press Releases |
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Destiny Pharma appoints MedPharm to develop new XF-platform drug formulations
Destiny Pharma, a clinical stage biotechnology company focused on the development of novel antimicrobial drugs, is pleased to announce that it has appointed MedPharm as its expert partner to develop new topical formulations of the Company’s novel XF-platform compounds. These new treatments for dermal and ocular infections are part of its second clinical programme to address the global problem of anti-microbial resistance (AMR). MedPharm is a world leading contract provider of topical and transdermal product design and formulation development services using sophisticated in vitro models to de-risk development programmes.
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Considerations for Choosing the Right Wearable Drug Delivery System
West Pharmaceutical Services, Inc.
For patients with chronic conditions, the use of injectable biologic therapies is on the rise. Biologics, while providing considerable therapeutic benefit, can also present several challenges for both drug manufacturers and patients. In particular, many biologics are highly viscous and others require large doses to be injected slowly over time. This can make it difficult to deliver a consistent dose every time, potentially impacting medication adherence.
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Industry Events |
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BioPharm America™ 2019—12th Annual International Partnering Conference
11-12 September 2019, Boston Convention and Exhibition Center (BCEC), Boston, MA 02210 USA
BioPharm America™ is a unique partnering event that forms the nexus of discovery and
realization. Startup companies, established biotech and entrepreneurs from academia
attend in search of finance, pharma and development partners. The event format highlights
innovation and promotes new business relationships by bringing dealmakers from the life
science ecosystem together to engage and de-risk the enormous task of drug development.
Life science executives from around the world gather to identify, meet and to enter
into strategic relationships facilitated by partneringONE®, the world’s leading
web-based partnering system. BioPharm America is the only event in North America
based on the same reputable formula as EBD Group’s acclaimed European events
BIO-Europe® and BIO-Europe Spring®. BioPharm America annually attracts 800+ delegates
from over 500 companies who participated in 2,300+ scheduled one-to-one meetings.
BioPharm America is now part of Biotech Week Boston, and together they draw a total
of over 4,500 life science leaders, scientists and innovators.
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