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PUBLICATIONS

European Biopharmaceutical Review

ebr
Autumn 2018

   
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Editor’s Letter

EBR's Editor, Dr Deborah O'Neil, details all the innovations touched upon in this issue and how the majority can enhance cancer treatment.
 
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peptides and proteins
Label-Free Biosensing

Protein Progression

Following a significant increase in quality, peptide and protein microarrays now have the potential to offer brand new opportunities in pharmaceutical and proteomics R&D, claims Güenther Proll at Biametrics.
 
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Process-Specific Versus Generic Host Cell Protein Impurity Assays

Biologics Process Analysis

Given the rise in therapeutic antibody production, it has become more important than ever to address issues associated with host cell proteins, as detailed by Ken Hoffman, Eric Bishop, Dr Alla Zilberman, and Dr Jared Isaac at Cygnus Technologies.
 
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Generating High-Quality Protein Reagents from Eukaryotic Cells

Cell Culture Considerations

Both Escherichia coli and eukaryotic systems have their pros and cons, yet the former is selected more often due to speed and cost implications. Dr Mark Abbott at Peak Proteins discusses the factors to be considered.


 
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Improving Pharmacokinetic Assays in a Regulatory Bioanalysis Setting

Applying Affimers

Dr Amanda Nicholl at Avacta Life Sciences expresses the fundamentality of pharmacokinetic assay results in the phases of drug development and how to increase the effectiveness and efficacy of antibody drug development.
 
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Peptides in Plasma

Determining Peptides

Determination in plasma can be particularly complicated, especially when dealing with peptides, but Professor Hermann Mascher at pharm-analyt believes it is still a route worth taking.
 
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Formulation and Quality Control
Purifying Oligonucleotides

Produce Potential

Dr Cecilia Unoson and Dr Lars Haneskog at Bio-Works Technologies delve into whether the necessary yield and purity of oligonucleotides can be attained through anion exchange chromatography.
 
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Innovations in Oncology
Advanced Therapies

Rising to the Challenge

Dr Fiona Thistlethwaite at The Christie Hospital and Dr Ian Thomas at Aptus Clinical explore the challenges of bringing advanced therapy medicinal products to market and the considerations that must be made.
 
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Tissue-Agnostic Approvals

A New Oncology Era

New advances in tumourigenesis have laid the foundations for a molecular marker that assists in defining and treating cancers, explains Dr Terese Johansson at NDA Group.
 
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Cancer Therapy Innovations

Oncological Advances

Dr Kathryn D Bungartz at N-of-One provides an overview of how advanced imaging techniques and improved preventative measures have transformed the world of cancer innovation.
 
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In Vitro Bioassays

Candidate Selection

The cancer immunotherapies field has made notable progress in its clinical application, and combination therapies may be a viable force to drive these advancements further, suggest Thibault Janss and Sofie Pattijn at ImmunXperts.
 
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Diafiltration of Antibody-Drug Conjugates

Novel TFF Capsule Evaluation

The teams at Sanofi and Merck Group demonstrate the advantages of antibody-drug conjugates as cancer chemotherapeutics.
 
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Bioelectronics
Electroceutical Therapy for Chronic Pain

Effective Electroceuticals

Dr Sree Koneru at BioElectronic Corporation and Dr Kenneth McLeod at the State University of New York in Binghamton, outline the benefits of electroceutical treatments for many neurological disorders and compare this to the widely recognised central sensitisation.
 
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Benefits of Bioelectronic Medicine

Theory to Game Changer

As the use of bioelectronics is on the rise following the adoption of electric devices as main treatment options, Pascaline Vancraeyenest at Healtech identifies how the reliance on drugs is potentially becoming limited.
 
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The Future of Bioelectronic Medicine

Targeted Technology

Dr Deepak B Thimiri Govinda Raj, Prasanna Subramaniam, Dr Sri Saran Venkatachalam, and Dr Dinh-Toi Chu at Envirotransgene Biosolutions examine why bioelectronic medicine is regarded as a disruptive technology in healthcare.
 
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biopharmaceutical technology
In Brief

GOAL!

Following this year's approval of the first RNA interference-based human therapy, EBR's Industry Advisor, Emile Bellott, takes a look at its new role as a game-changer within the biopharma industry.
 
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Published quarterly in
January, April,
July, and October

News and Press Releases

MyMD Pharmaceuticals Announces Issuance of U.S. Patent for Synthetic Cannabinoid Compounds for Treating Neuroinflammatory and Neurodegenerative Diseases

MyMD Pharmaceuticals Inc., a clinical stage pharmaceutical company committed to extending healthy lifespan by focusing on developing two therapeutic platforms, today announced that the United States Patent and Trademark Office (USPTO) has issued U.S. Patent No. 11,085,047 titled “Synthetic Cannabinoid Compounds for the Treatment of Substance Addiction and Other Disorders.”
More info >>

White Papers

Cleaning Validation: What do you need to consider to ensure a successful outcome?

RSSL

Cross contamination must be avoided in the Pharmaceutical industry at all costs and successful cleaning validation ensures that patients are not put at risk due to cross contamination. The process can be divided into a number of sections each of which must be fully understood and areas of concern addressed to ensure a successful outcome across the entire process. This spans both the manufacturing and subsequent analytical and microbological support. The data used to confirm a positive/successful cleaning validation is underpinned by the results of validated analytical methods. It is essential that these results are truly representative as patient safety is based upon the absence of equipment residues. So what are those areas of concern, what affects your ability to get a successful outcome and what do you need to consider when carrying out a Cleaning Validation exercise?
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Industry Events

Pharma Integrates 2021

16 November 2021, VIRTUAL CONFERENCE

Now in its tenth year, Pharma Integrates is a unique event bringing together pharma and healthcare leaders across the Pharmaceutical pipeline to address their needs, to share insights and create debate on crucial topics that influence the future of patient outcomes.
More info >>

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