spacer
home > ebr > autumn 2018 > rising to the challenge
PUBLICATIONS
European Biopharmaceutical Review

Rising to the Challenge

Advanced therapy medicinal products (ATMPs) represent one of the fastest-growing areas of clinical research due to their potential to cure severe chronic conditions. Despite the important health benefits that ATMPs are expected to bring, relatively few have reached the market, and several have been subsequently withdrawn. Oncology indications remain the largest sector in the UK, and, while Phase 3 trials have increased, most are still in early phase development. Therefore, it is likely to be several years before the full potential for ATMPs is translated into meaningful patient benefit and will be dependent upon researchers overcoming numerous challenges, including recruitment, operational, and safety considerations. Overcoming these challenges requires innovation, collaboration, and sound strategic development to ensure ATMPs are brought to market efficiently and without a prohibitive impact on drug budgets. This article will discuss how researchers in the UK are at the forefront of this scientific endeavour, with several exciting collaborations, backed by Innovate UK, generating optimism for future success.

The ATMP Market

ATMPs are a new generation of treatments that use gene therapy, cell therapy, and tissue engineering. They offer unprecedented promise for the treatment of diseases or injuries that currently have a high, unmet medical need, such as Alzheimer’s disease, cancer, muscular dystrophy, ophthalmology, and skin in burns victims. Given their curative potential in severe chronic conditions, ATMPs are, unsurprisingly, one of the fastest-growing areas of research, with an estimated global market opportunity of up to £14 billion by 2025, with predicted additional year-on-year growth potential of 25% to 2030.

While optimism may be justified for the future of ATMPs, the situation today is that this technology remains extremely complex and expensive and is only available to a small number of patients. Results from clinical studies have shown promise, but few products have yet to reach the market – only 10 have been approved in Europe, most recently being Alofisel (to treat anal fistulas in Crohn’s Disease) from TiGenix/Takeda. Of these, four have since been withdrawn. This is slow progress considering that the first ATMP, chondrocelect (to repair damage to the cartilage in the knee), was approved nine years ago, especially given the level of interest and investment in the field.

Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
Dr Fiona Thistlethwaite is a Medical Oncology Consultant within the experimental cancer medicine team at The Christie Hospital, UK, and Honorary Senior Lecturer at the Division of Cancer Sciences, Faculty of Biology Medicine & Health, at The University of Manchester, UK. Fiona is also the Director for iMATCH.

Dr Ian Thomas is a drug development expert with several decades of early and late phase oncology experience. In his role as Clinical Delivery Director for Aptus Clinical, a specialist CRO, Ian leads the company’s advanced therapy clinical development activities and is extensively involved in supporting iMATCH.
spacer
Dr Fiona Thistlethwaite
spacer
spacer
spacer
Dr Ian Thomas
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Turkish Cargo keeps growing in the first quarter of 2019

Maintaining its accomplished operations from Ataturk and Istanbul airports as "Dual Hub", the global brand of Turkish Cargo continued its strong growth momentum during the first quarter of the year despite the shrinkage of the global air cargo sector.
More info >>

White Papers

A Rules Based Approach to Labelling and Artwork Management

Kallik

Many organisations today are experiencing unprecedented demands from regulatory authorities and consumers alike for product labelling to be made clearer and more informative. Forthcoming regulations (including the new EU MDR regulations coming into force May 2020) also require that labelling content to be published electronically in addition to print. As companies seek to continuously differentiate themselves in established markets as well as gain entry into new territories, the increase in both volume and complexity of product and market variations will have a direct impact on labelling.
More info >>

 
Industry Events

BioPharm America™ 2019—12th Annual International Partnering Conference

11-12 September 2019, Boston Convention and Exhibition Center (BCEC), Boston, MA 02210 USA

BioPharm America™ is a unique partnering event that forms the nexus of discovery and realization. Startup companies, established biotech and entrepreneurs from academia attend in search of finance, pharma and development partners. The event format highlights innovation and promotes new business relationships by bringing dealmakers from the life science ecosystem together to engage and de-risk the enormous task of drug development. Life science executives from around the world gather to identify, meet and to enter into strategic relationships facilitated by partneringONE®, the world’s leading web-based partnering system. BioPharm America is the only event in North America based on the same reputable formula as EBD Group’s acclaimed European events BIO-Europe® and BIO-Europe Spring®. BioPharm America annually attracts 800+ delegates from over 500 companies who participated in 2,300+ scheduled one-to-one meetings. BioPharm America is now part of Biotech Week Boston, and together they draw a total of over 4,500 life science leaders, scientists and innovators.
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement