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European Biopharmaceutical Review

ebr
Summer 2019

   
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Genomics and DNA
Advancements in Genealogy

The DNA of a New Industry

Futura Genetics’ Efi Binder delves into the rapidly progressing field of genome sequencing, expanding on the decreasing costs that are associated with this type of testing.
 
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ADCs as Therapeutics
Leveraging Automated Discovery Platforms

Easy as ADC

Dr Xin Liu at Sphere Fluidics emphasises the efficacy and reduced toxicities of novel antibody-drug conjugates as a promising yet costly means to treating life-limiting diseases.
 
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Analytical Techniques in Therapeutics

ADC Characterisation

Christopher M Bianchetti PhD, Henry J Parker, Katherine C Hanson PhD, and Stephen Gacheru PhD at PPD Laboratories illustrate how monoclonal antibody-based therapeutics are advancing cancer treatment.
 
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Antibody-Drug Conjugates in Chemotherapy

The ADC Jigsaw

Antibody-drug conjugates are good contenders in the fight against cancer. Dr Jenny Thirlway at Iksuda outlines how this route of cancer treatment is more effective in eradicating cancer cells and reducing side effects.
 
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Features
Choosing the Right Biomaterial

A View from the Bench

Barbara Vanhoecke at Rousselot investigates the possibility of removing endotoxins that have proven to be a hindrance in instances where using gelatin would be preferable.
 
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The Cancer Problem

Closer to the Cure

Christian Rommel at Roche advises companies to refrain from treating every step forward in cancer research as a potential cure. Rather, scientists should accept that finding a cure will be a more difficult journey than anticipated.
 
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Immunoncology Drug Development

Do More With Less

Dr Katie Chapple at Sartorius Stedim Biotech and Andrea Gomez-Donart at IntelliCyt outline the current advances in immunoncology, looking specifically at drugs that harness the immune system.
 
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Antibiotic Resistance

Fighting the Global Threat

DAs antibiotic resistance continues to plague the healthcare industry, Adrian Fellows at AGA Nanotech urges companies to unite and educate
 
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Achieving the Full Potential of Immunoncology

Leveraging Novel Therapeutics and Diagnostic Assays

Marisa Pearce at Molecular MD, an ICON company, argues that, although immunotherapy is nothing new, it has much untapped potential yet to be explored.
 
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Translational Safety

The Next Frontier

InSphero’s Judi Wardwell, Dr Radina Kostadinova, and Professor Armin Wolf believe in vitro tissue models to be the way forward in reducing attrition rates of drug candidates, ultimately improving patient safety and return on investment.
 
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Fermenting Peptides and Proteins

The Renaissance of Microbial Fermentation

The advent of cell culture systems ultimately led to increased interest of microbial-produced biopharmaceuticals, as told by Dr Vladas Bumelis at Northway Biotechpharma.

 
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Analytical Methods
AI and Multifactorial Data Analytics

A New Lens

Analytical tools are necessary for understanding the architecture of multifactorial diseases. Steve Gardner at RowAnalytics introduces the new generation of artificial intelligence and data analytics that can aid in the untangling of disease risk.


 
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Examining Process Residuals

Mass Spectrometric Analysis of Process-Related Impurities

Dr Richard L Easton and Dr Andrew J Reason at BioPharmaSpec demonstrate why mass spectrometry is a highly versatile tool for residual detection, even in the most complex of mixtures.
 
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Neurodegenerative Diseases
Systems Medicine and Drug Repurposing

An Answerable Challenge

Neurodegeneration and neurological disorders as a whole could be considered as the main cause of disability-adjusted years. Dr Hermann Mucke at H.M. Pharma Consultancy encourages the exploration of new drug combinations to drive treatment of such diseases.
 
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Targeting Aβ Oligomers

The Future of R&D in Alzheimer’s Disease

Dr Neil Cashman and Dr James W Kupiec at ProMIS Neurosciences explain the ways in which new investigational drugs are transforming clinical trial design and the R&D landscape.
 
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Regulars
In Brief

Great Expectations

EBR’s Industry Advisor Emile Bellott reviews rare disease progress in the biopharmaceutical arena.

 
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Immunology

The Factory for Next- Generation Therapies

EBR’s Editor Dr Deborah O’Neil recounts the themes of the issue, warning of the dangers of antimicrobial resistance while celebrating advancements in personal genetic data.
 
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Edited by
Dr Deborah O'Neil,
Chief Executive and Scientific Officer,
NovaBiotics Ltd
Published quarterly in
January, April,
July, and October

News and Press Releases

Francine Lane Recipient of 2019 DIA Global Inspire Award

JERSEY CITY – March 21, 2019 – Francine Lane, TrialScope Vice President of Global Transparency, has received a 2019 Global Inspire Award from the Drug Information Association (DIA). Lane, chair of the DIA’s Clinical Trial Disclosure Community, and Robert Paarlberg, past chair, are co-recipients of the Community Engagement Award. The award recognizes DIA community chairs for consistently driving engagement while advancing knowledge and thought leadership within their membership communities.
More info >>

White Papers

Interface: Drug Delivery Devices

Phillips-Medisize

A family is packing for its annual summer trek to the cottage by the lake. Along with fishing gear, sunscreen, and life vests, the checklist also includes another kind of life saver – an autoinjector that delivers two doses of epinephrine to treat anaphylaxis, a severe and potentially lifethreatening allergic reaction.
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Industry Events

CPhI Worldwide

5-7 November 2019, Frankfurt, Germany

Join the World's Largest Pharma Event As it Celebrates its 30th Anniversary! Taking place from 5-7 November 2019 in Frankfurt, Germany, the event will bring together more than 45,000 visiting pharma professionals from around the globe and over 2,500 exhibiting pharma companies from every stage of the pharmaceutical supply chain - from ingredients and machinery to outsourcing services, packaging and more!
More info >>

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