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European Biopharmaceutical Review

The Future of R&D in Alzheimer’s Disease

Earlier this year, the failures of two high-profile, antiamyloid- beta (Aβ) monoclonal antibodies (mAbs) in late-stage clinical trials have sharpened the focus on two key issues that currently dominate the quest to establish effective treatments for Alzheimer’s disease (AD): the need to develop drugs that are highly selective for the Aß conformation known to be the pathogenic cause of AD (ie, soluble neurotoxic Aβ oligomers [AβOs]) and the need to employ emerging AD biomarkers to dramatically transform clinical trial design and enable cost-effective, earlier go/nogo decisions on investigational therapeutics.

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Dr Neil Cashman is a Physician and Scientist recognised worldwide as one of the leading researchers pioneering the emerging fields of prion biology and protein misfolding disease, in particular, Alzheimer’s disease and amyotrophic lateral sclerosis. His research has attracted more than US $50 million in funding, including grants from the National Institutes of Health. Neil is a past recipient of the Jonas Salk Prize for biomedical research and current Fellow of the Canadian Academy of Health Sciences.

Dr James W Kupiec has led both early- and late-stage development teams working on investigational therapies for a wide variety of neurologic and psychiatric disorders for the past 25 years. He began his career practising internal medicine, serving on faculty at both the University of Rochester School of Medicine, US, and the SUNY Upstate Medical University, US, before shifting to commercial posts. James most recently served as Vice President, Global Clinical Leader for Parkinson’s Disease, and Clinical Head of the Neuroscience Research Unit in Cambride for Pfizer.
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Dr Neil Cashman
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Dr James W Kupiec
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