spacer
home > ebr > summer 2004 > apoptosis and chemotherapy: helping cancer cells to die
PUBLICATIONS
European Biopharmaceutical Review

Apoptosis and Chemotherapy: Helping Cancer Cells to Die

For an organism to develop multicellular tissues and organs, and to maintain cellular homeostasis during adulthood, the formation of new cells needs to be co-ordinated with the elimination of redundant and damaged cells. Apoptosis is the morphological manifestation of programmed cell death; the predominant mechanism that opposes and compliments cell proliferation. An imbalance between cell birth and death has pathological consequences: many chronic and acute degenerative disorders, as well as immunodeficiency diseases and infertility, are characterised by abnormally high rates of cell death in certain tissues. Conversely, suppression or retardation of apoptosis are distinguishing features in autoimmunity and cancer. Here I shall confine my discussion to the impact our current understanding of apoptotic signalling, as well as the mechanics of apoptosis, have on oncology drug discovery and development. Selective activation of programmed cell death in cancer cells is particularly desirable because apoptosis, as opposed to necrosis and other catastrophic cell injuries, leads to complete destruction and eradication of the aberrant cells without inflammatory and immunological side-effects.

Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
By Peter M Fischer, Head of Discovery Research at Cyclacel Limited

Peter M Fischer received his PhD from Deakin University, Australia. He has worked in academia, as well as the biotechnology and pharmaceutical industries on peptidomimetic and traditional medicinal chemistry projects related to drug discovery. For the last six years, he has been with the cancer research company Cyclacel, Scotland, for whom he established structure-based design and medicinal chemistry capabilities. He is currently Head of Discovery Research and focuses on cell cycle-related drug discovery targets, including CDKs and other protein kinases.

spacer
Peter M Fischer
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Introducing Signant Health [Formerly CRF Bracket] and the Industry’s Most Comprehensive Patient-Centric Suite for Clinical Research

Philadelphia and London – June 10, 2019: CRF Bracket, formed by the 2018 merger of CRF Health and Bracket, today launched as Signant Health (signanthealth.com). Uniting eCOA, eConsent, Patient Engagement, IRT, Clinical Supplies and Endpoint Quality into the industry’s most comprehensive patient-centric suite, Signant makes it easier to participate in – and sites and study teams to run – clinical trials. This intense focus on the patient experience, deep therapeutic area expertise and global operational scale enable sponsors and CROs to extend the reach of drug development, expand patient opportunities and improve data quality.
More info >>

White Papers

Clinical Trials in Russia Orange Paper: Summary of Year 2013

Synergy Research Group

Russia remains a very popular geography for local, regional, and global pharmaceutical companies to conduct clinical trials. Sponsors mention the following reasons for conducting studies in Russia: 1. Fast patient enrollment due to the centralized medical infrastructure. 2. Nearly 100% patient retention 3. GCP trained and certified Investigative Sites generating high quality data 4. Low cost: Average per patient cost is 60% to 70% below US and European prices due to the low cost of Investigators and the high concentration of patients in therapeutically aligned medical centers
More info >>

 
Industry Events

CPhI & P-MEC India

26-28 November 2019, India Expo Centre, Greater Noida, Delhi NCR, India

As the pharma industry looks increasingly towards India for high quality, low cost pharma solutions, CPhI & P-MEC India is the ideal event for companies wanting to pick up on the latest trends and innovations the market has to offer. At CPhI & P-MEC India, you will meet the movers and shakers from India's pharma machinery, technology and ingredients industries, giving you a competitive advantage that will help grow your business.
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement