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European Biopharmaceutical Review

Reproducible, Low Cost Arraying Achieved with a Multiplexed Approach

Microarrays: A Powerful but Imperfect Tool

Microarrays are well-recognised as powerful tools, that enable the global characterisation of physiological state at the genomic level (1-3). However, the widespread use of microarrays outside basic research is hindered by high costs, inadequate reproducibility (4) and bioinformatic limitations (5). Such problems have resulted in barriers for the implementation of this technology in clinical diagnostic applications, which is arguably the logical 'endpoint' for microarray analysis/acceptance (6,7).

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By Dr Samuel D Conzone, Manager of Research and Development and Dr Rajendra J Redkar, R&D Scientist, at Schott Nexterion

Dr Samuel D Conzone obtained his BSc degree from Alfred University, New York in 1994 with a BSc in Ceramic Science. He then attended the University of Missouri-Rolla, conducting research on biodegradable, radioactive glass microspheres intended for the in vivo treatment of ailments such as liver cancer and rheumatoid arthritis. He received his PhD in Ceramic Engineering in June 1999, and his research work was rewarded with the Norbert J Kreidl award for excellence in the area of glass science. Dr Conzone then proceeded to begin his career at Schott Glass Technologies (Duryea, PA) as an R&D Developmental Scientist, before becoming the Manager of Research and Development for Schott Nexterion activities in 2002. Dr Conzone is currently the author or co-author of 20 publications and 13 patents/patent applications.


Dr Rajendra J Redkar obtained his BSc and MSc degrees from the University of Poona, India in Microbiology. After working in the biotechnology industry for 10 years he attended Auburn University, USA, and conducted research in understanding the gene expression changes under NaCl-stress using Aspergillus nidulans as a model system. Dr Redkar received his PhD in Microbiology/Molecular Biology in April 1995. He then began his career at the University of Scranton, USA as a Research Scientist, and developed DNA-based diagnostic assays for pathogens and co-ordinated genome sequencing projects. In June 2001, he joined Schott Nexterion as an R&D Scientist and supported the development of coated slides for microarray applications. Dr Redkar has authored or co-authored 18 publications in peer-reviewed journals.

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Dr Samuel D Conzone
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Dr Rajendra J Redkar
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IONTAS announces a new collaboration to identify novel immunotherapy targets

Cambridge, UK, 07 May 2020: IONTAS Limited (IONTAS), a leader in the discovery and optimisation of fully human antibodies, today announced it has entered into a collaboration agreement with Inotrem, a specialist in immunotherapy for acute and chronic inflammatory syndromes. As part of the agreement, IONTAS will apply its Mammalian Display technology to identify antibodies involved in the TREM-1 pathway.
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