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home > ebr > spring 2004 > in vivo veritas? cell-based assays for identifying rtk inhibitors
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European BioPharmaceutical Review

In Vivo Veritas? Cell-Based Assays for Identifying RTK Inhibitors

Receptor tyrosine kinases (RTKs) play an important role in many fundamental cellular processes including cell metabolism and survival, as well as cell proliferation and differentiation. Deregulated RTK signalling is critically involved in the development and progression of human cancer. Therefore, RTKs represent attractive targets for anti-cancer therapy. Many methods have been explored to measure the activation and inhibition of RTKs in vitro and in living cells. This article discusses the application of functional cell-based screenings for the identification of specific RTK inhibitors.

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By Tea Gunde, Scientist at ESBATech AG

Tea Gunde received her first degree in Biology from the University of Zurich. She then joined ESBATech for her PhD studies on the subject of functional screening systems in yeast, where she was instrumental in the development of the assays for the receptor tyrosine kinases. Her experience and expertise gained during her PhD studies was put to good use in the subsequent exploitation for high-throughput small compound screens for kinase inhibitors and their characterisation in follow-up experiments.

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Tea Gunde
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