samedan logo
 
 
 
spacer
home > ebr > spring 2004 > in vivo veritas? cell-based assays for identifying rtk inhibitors
PUBLICATIONS
European Biopharmaceutical Review

In Vivo Veritas? Cell-Based Assays for Identifying RTK Inhibitors

Receptor tyrosine kinases (RTKs) play an important role in many fundamental cellular processes including cell metabolism and survival, as well as cell proliferation and differentiation. Deregulated RTK signalling is critically involved in the development and progression of human cancer. Therefore, RTKs represent attractive targets for anti-cancer therapy. Many methods have been explored to measure the activation and inhibition of RTKs in vitro and in living cells. This article discusses the application of functional cell-based screenings for the identification of specific RTK inhibitors.

Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
By Tea Gunde, Scientist at ESBATech AG

Tea Gunde received her first degree in Biology from the University of Zurich. She then joined ESBATech for her PhD studies on the subject of functional screening systems in yeast, where she was instrumental in the development of the assays for the receptor tyrosine kinases. Her experience and expertise gained during her PhD studies was put to good use in the subsequent exploitation for high-throughput small compound screens for kinase inhibitors and their characterisation in follow-up experiments.

spacer
Tea Gunde
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Shionogi Announces Publication of Two Studies in The Lancet Infectious Diseases Highlighting The Efficacy And Safety of Cefiderocol For The Treatment of Infections Due to Aerobic Gram-Negative Bacteria in Adults With Limited Treatment Options

Shionogi announces publication of data from two of its clinical trials; APEKS-NP and CREDIBLE-CR in the journal The Lancet Infectious Diseases.
More info >>

White Papers

Mouse Models for Evaluation of Vaccines and Therapeutics Against Staphylococcal Infections

IBT Bioservices

Introduction Staphylococcus aureus (SA) is a ubiquitous, formidable Gram-positive pathogen associated with skin and soft tissue, as well as lifethreatening systemic infections. SA is a leading cause of hospital- and community-associated infections worldwide, affecting humans and animals. The wide range of pathologies reflects the diverse abilities of this microbe to escape the innate and adaptive immune response using virulence factors. Since its first emergence in the 1960s methicillin-resistant SA (MRSA) has become endemic in hospitals and healthcare settings worldwide. In the 1990s, community associated MRSA strains (CA-MRSA) emerged, and are spreading worldwide posing a major global challenge.
More info >>

 
Industry Events

World Vaccine Congress Europe

18-21 October 2020, Barcelona, Spain

The World Vaccine Congress is an award-winning series of conferences and exhibitions that have grown to become the largest and most established vaccine meeting of its kind across the globe. Our credibility is show through the prestigious scientific advisory board that spend months of hard work creating a new and topical agenda, year on year.
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement