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European Biopharmaceutical Review

The Chemical Synthesis of Proteins: Beyond the Genome

The pivotal role of proteins in biological processes and disease, and the increasing success of protein therapeutics, has led to the increased development of technologies for their production. In particular, the incorporation of unnatural amino acids and chemical modifications into proteins has enabled a wide variety of derivatives to be rationally engineered for applications in all facets of basic research, drug discovery, diagnostics and therapeutics. The ability to engineer protein sequences in a site-specific manner is thus highly prized and opens up many powerful new avenues.

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By Dr Graham Cotton, PhD, Senior Research Scientist at Albachem Ltd

Dr Graham Cotton received his BSc in Chemistry from Durham University and gained his PhD at the University of Edinburgh in the field of synthetic peptide vaccines and therapeutics. Having continued these studies as a Postdoctoral Worker, he moved to Rockefeller University, New York in 1996, where he spent over four years as a Postdoctoral Fellow developing novel protein engineering technologies and their application for elucidating the molecular events regulating cell signalling processes. He then joined Amersham Biosciences to further develop this research area before moving to Albachem Ltd in 2002. As Senior Research Scientist, he is applying his multi-disciplinary experience to focus on new chemical and biological approaches to protein therapeutics.

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Dr Graham Cotton
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