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| home > ebr > spring 2003 > large-scale, comprehensive quality control and analysis of high-throughput screening data |
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European Biopharmaceutical Review
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High-throughput screening (HTS) is used to search a vast area of the chemical universe for bioactive compounds and provides biological data on different targets from standardised, sensitive and well-controlled experiments for hundreds of thousands of compounds. However, this wealth of information is rarely exploited to its fullest extent and expensive resources are therefore often wasted.
In order to address this problem, intelligent methods and software to process and combine results from different HTS screens, secondary tests and lead profiling experiments are being developed. Data quality, biological side effects and chemical relationships are addressed at every stage, improving guidance for compound selection in screening and optimisation cycles. In support of the screening workflow, the analysis process consists of the following five steps: quality control, standardisation, compound classification, structure-activity relationship (SAR) analysis and pharmacological classification.
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DIA Annual EuroMeeting
26-28 March 2012, Copenhagen, Denmark
The EuroMeeting attracts more than 3,000 professionals from over 50 countries. It brings together professionals from the biopharmaceutical industry, contract service organisations, clinical research, regulatory agencies, health ministries, patients’ organisations and universities. This convergence affords attendees the opportunity to network with professional colleagues from around the world.
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