|
 |
| home > ebr > spring 2003 > large-scale, comprehensive quality control and analysis of high-throughput screening data |
 |
 |
PUBLICATIONS |
European BioPharmaceutical Review
|
High-throughput screening (HTS) is used to search a vast area of the chemical universe for bioactive compounds and provides biological data on different targets from standardised, sensitive and well-controlled experiments for hundreds of thousands of compounds. However, this wealth of information is rarely exploited to its fullest extent and expensive resources are therefore often wasted.
In order to address this problem, intelligent methods and software to process and combine results from different HTS screens, secondary tests and lead profiling experiments are being developed. Data quality, biological side effects and chemical relationships are addressed at every stage, improving guidance for compound selection in screening and optimisation cycles. In support of the screening workflow, the analysis process consists of the following five steps: quality control, standardisation, compound classification, structure-activity relationship (SAR) analysis and pharmacological classification.
|
Read full article >>
|
 |
 |
 |
| Rate this article |
You must be a member of the site to make a vote. |
|
Average rating: |
0 |
| | | | | |
|
 |

 |
Industry Events |
 |
Clinical Trials in CNS
25-26 November 2008, Copthorne Tara Hotel, London, UK
SMi present their 7th annual conference… Clinical Trials in CNS 25th to 26th November 2008, Copthorne Tara Hotel, London, UK
More info >> |
|
 |
News and Press Releases |
 |
Financial Times hosts the Global Pharmaceutical and Biotechnology Conference
13th November 2008
More info >> |
|
|