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| home > ebr > spring 2003 > live cells as drug discovery tools - high-throughput, high-content screening |
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European BioPharmaceutical Review
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| In the drug discovery arena, the better the quality of data, the better the chance of striking 'therapeutic gold'. To bridge the gap from candidate compound to blockbuster drug, the assay should mimic the drug target interactions that occur in a living human cell. Traditional screening practices have been based within the non-cellular environment in order to maximise sample throughput and generate simple one-dimensional data. More recently, the advent of low-throughput, high-content systems have allowed more relevant and complex cell-based assays to be performed. However, cell-based, high-content assays and high-throughput screening need not be mutually exclusive - high-information, high-throughput cell-based technologies are available. A new laser scanning system can provide greater insight into the events occurring at the living cell level and pull low-throughput secondary screening assays into the primary screening stage. |
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