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| home > ebr > summer 2003 > mass-based fraction collection of crude synthetic peptides in analytical and preparative scale for cancer treatment |
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European BioPharmaceutical Review
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| Synthetic peptides become more and more important as drug candidates in the treatment of a variety of diseases. A particular therapeutic focus for synthetic peptides is cancer treatment (1, 2). In order to keep pace with the growing number of newly synthesised peptides, peptide purification should not represent a bottleneck in the drug discovery process. Since the target masses of synthetic peptides are well known, mass-based fraction collection represents an efficient technique for their purification. In contrast to fraction triggering with less specific detectors, employing a mass selective detector only leads to the purification of the target mass in each run. Consequently, it is not necessary to pick out the compound of interest from a series of redundant fractions. |
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