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European Biopharmaceutical Review

SPR-MS in Functional Proteomics

As the advent of proteomics switches the emphasis from genes to proteins, increased scientific attention is being paid to techniques that produce detailed information on human proteins. Much interest has been concentrated on identification and structural characterisation of the proteins in a cell, using techniques such as mass spectrometry (MS). The true value of genomic information however, will only be realised when this data is combined with functional characterisation of the proteins in question, using techniques such as surface plasmon resonance (SPR). It is not often that two analytical techniques can be successfully combined to correlate data, whilst simultaneously increasing the quality and quantity of output - but this is the case with SPR and MS.

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By Dr Stefan Löfås, Vice President and Chief Scientific Officer at Biacore AB

Dr Stefan Löfås holds a PhD and BSc in Organic Chemistry. He has gained extensive technical and scientific experience in the development and commercialisation of bioanalytical instrumentation at Biacore AB, having worked for the company since 1985. He has been deeply involved in the development of Biacore's sensor chip chemistry and applications. He was recently appointed Chief Scientific Officer with responsibility for technical development projects, external scientific collaborations and technical aspects on IPR portfolio. Prior to this, Dr Löfås was Director of Biacore's biochemistry & chemistry department within R&D.

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Dr Stefan Löfås
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