|
|
|
European Biopharmaceutical Review
|
The words prep, process and polymerics are becoming more and more associated together in the biopharma industry as new macroporous polymeric resins are increasingly used in the final 'polishing' of pharma products. Originally polymeric resins were designed as soft gels like cellulose-based gels with low cross linker contents that shrank and swelled with varying solvent conditions and so were not ideal for HPLC due to their poor pressure stability. These gels are classified as microporous gels. They have completely separate and distinct physical and chemical characteristics compared to macroporous gels. Over the years however, polymeric gels have been grouped together and silica-based gels have remained the media support of choice for reversed phase HPLC.
Advances in polymeric design and the inert characteristics of the support have allowed companies in the biopharma industry to re-examine polymerics as viable, if not better, alternatives to silica-based materials. Here we discuss some of the benefits offered by polymerics, making them a viable and economic chromatographic solution for preparative and process chromatography. Polymeric resin design has long since overcome the problems associated with soft gels such as poor mechanical stability, extreme particle swell or shrinkage with solvent composition, low pressure rating and long runtimes, thus making the process less time-consuming, easier and more reproducible for mass production scale.
|
Read full article from PDF >>
|
|
 |
|
| Rate this article |
You must be a member of the site to make a vote. |
|
Average rating: |
0 |
| | | | | |
|
|
 |
Industry Events |
 |
6th European Forum for Qualified Person for Pharmacovigilance (QPPV)
24-26 April 2012, London, UK
This event is for European qualified persons for pharmacovigilance; deputy qualified persons; senior pharmacovigilance regulators and inspectors; CROs and consultants providing QPPV services; and national responsible persons for pharmacovigilance.
More info >> |
|
 |
News and Press Releases |
 |
Pantec Biosolutions Showcases P.L.E.A.S.E.® Professional at the IMCAS Annual Congress
Pantec Biosolutions AG, the developer and manufacturer of P.L.E.A.S.E.® Professional, a state of the art portable laser device that sets new standards for safety, precision and versatility, today announced that it will present its recently launched P.L.E.A.S.E.® Professional laser device at the International Master Course on Aging Skin (IMCAS) from 26th-29th January 2012 in Paris, France.
More info >> |
|
|
