spacer
home > ebr > summer 2003 > are 'polymerics' coming of age?
PUBLICATIONS
European Biopharmaceutical Review

Are 'Polymerics' Coming of Age?

The words prep, process and polymerics are becoming more and more associated together in the biopharma industry as new macroporous polymeric resins are increasingly used in the final 'polishing' of pharma products. Originally polymeric resins were designed as soft gels like cellulose-based gels with low cross linker contents that shrank and swelled with varying solvent conditions and so were not ideal for HPLC due to their poor pressure stability. These gels are classified as microporous gels. They have completely separate and distinct physical and chemical characteristics compared to macroporous gels. Over the years however, polymeric gels have been grouped together and silica-based gels have remained the media support of choice for reversed phase HPLC.

Advances in polymeric design and the inert characteristics of the support have allowed companies in the biopharma industry to re-examine polymerics as viable, if not better, alternatives to silica-based materials. Here we discuss some of the benefits offered by polymerics, making them a viable and economic chromatographic solution for preparative and process chromatography. Polymeric resin design has long since overcome the problems associated with soft gels such as poor mechanical stability, extreme particle swell or shrinkage with solvent composition, low pressure rating and long runtimes, thus making the process less time-consuming, easier and more reproducible for mass production scale.


Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
By Dr Mark Millichip, HPLC Applications Technical Support Specialist at Polymer Laboratories Ltd

Dr Mark Millichip has been with Polymer Laboratories for three years as an HPLC Technical Support Specialist, with roles in customer support, project management and applications, and product research and development. Mark's chromatographic expertise comes from several years of post-doctoral biochemistry research on various projects at several UK universities, where he was involved in the characterisation, isolation and purification of biomolecules, including proteins and peptides, lipids, carbohydrates and oligonucleotides.

spacer
Dr Mark Millichip
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Kallik’s Release 6 sets new benchmarks for speed, accuracy and efficiency

Tamworth, UK – 15 June 2019 – Global provider of labelling and artwork management solutions, Kallik, is launching an update to its AMS360 solution – its Release 6, transforming the experience of the business user, whilst defining new benchmarks for speed, accuracy, and efficiency of global labelling and artwork processes.
More info >>

White Papers

Achieve full compliance with tamper-verification pharma solutions

UPM Raflatac

UPM Raflatac has developed a range of pharmaceutical labelling products to support compliance with the Falsified Medicines Directive on packaging for prescription drugs and high-risk, over-the-counter medicines. Few solutions offer the same ease of adoption for meeting the February 2019 deadline.
More info >>

 
Industry Events

ELRIG Drug Discovery 2019 – Looking Back to the Future

5-6 November 2019, ACC, Liverpool

Now in its 13th year, ELRIG’s flagship conference Drug Discovery 2019 will take place at ACC in Liverpool. This year’s focus, ‘A Look Back to the Future’ is planned to include plenary introductions assessing how we got to where we are now and setting the challenges for discovering the drugs of the future. These will be followed by cutting edge talks and examples of new directions in drug discovery. Our scientific programme will feature over 40 world-class speakers with 6 main session tracks. In partnership with key academic and charitable groups, we will also run joint disease and biology-oriented tracks focusing on the basic sciences that underpin successful drug discovery.
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement