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European BioPharmaceutical Review

Emerging Changes in the Management of Clinical Trials in NHS Organisations

In recent years single specialist clinical trial sites have experienced various difficulties (see Figure 1). Sites have struggled to withstand fluctuations in workload and many have taken unprofitable work to meet overheads and fixed employment costs. In some cases units were no longer able to support their own account research, whilst exit costs were prohibitive. To add to this pressure, income from NHS run clinical trials has impacted on trust operational budgets, adding extra responsibility to deliver key NHS reforms. In order to minimise the risk, four options seemed possible:

1. Close down - however the Department of Health acknowledges research as essential for promotion of health and wellbeing and emphasises the importance of commercially-funded clinical trials in developing beneficial treatments for NHS patients (1,2)
2. Effective marketing to gain more work, either in the same therapeutic area (provided that sufficient work and patient pools exists) or expand into other therapeutic areas (which may require additional expertise and expense)
3. Focus only on academic clinical trials - but long lead times may not solve the immediate problem
4. Team up with other sites to pool expertise


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By Roger Bullock, Principal Investigator and Director and Charlotte Rose, Business Manager at the Kingshill Research Centre

Dr Roger Bullock is the Principal Investigator and Director at the Kingshill Research Centre and has over 10 years' clinical trials experience. He is also Consultant and Manager of the Old Age Psychiatry Department, Swindon in the Avon and Wiltshire Mental Health Care Partnership NHS Trust. Dr Bullock completed his preclinical medical training at Oxford University, gaining an BA (Hons) in Physiological Sciences in 1978 (converted to MA in 1985). This was followed by clinical medical training at St Bartholomew's in London. In 1990, Dr Bullock undertook postgraduate psychiatric training including higher specialist training in geriatric psychiatry. He is now sharing his experience and knowledge by acting as Speciality Tutor in Old Age Psychiatry for Wessex and Associate Professor for St George's University Teaching Hospital, Grenada.


Charlotte Rose has worked at the Kingshill Research Centre for five years as a Business Manager and is about to complete an MBA at Bath University. Prior to this post she has worked in the food and health group at the Consumers Association as a freelance Market Analyst and as a Retail Manager. She has a BSc in Chemistry and an MA in Applied Social and Market Research.

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Dr Roger Bullock
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