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European BioPharmaceutical Review

Biopharmaceutical Manufacturing: Past, Present and Future

In 2000 and 2001, the conference circuit was buzzing with the apparent and imminent shortage of manufacturing capacity for recombinant biotherapeutics. Predictions were that by 2005 only one in four new monoclonals would have sufficient capacity to satisfy market demand. The 'capacity crisis' was predicted for mammalian facility with near certainty, and anticipated for microbial capacity shortly afterwards.

A lot has changed in the last two years, and the market in 2003 is rather different. This article takes a look back into the origins of the capacity crisis, examines the status of the market in 2003 and outlines the landscape for a more speculative article on the future of biomanufacturing which will be published in the next issue.


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By Sharon Grimster, Director of Westerly Projects Ltd

Sharon Grimster started her career working on clinical trials at Guys Hospital Medical School in London. She then moved to Celltech, working in research for four years prior to taking up various management positions within contract manufacturing. Sharon subsequently managed preclinical and clinical development programmes for both new chemical entities and biological entities. Following the mergers with Chiroscience and Medeva, Sharon became Head of Biologics Manufacturing Development. She left Celltech in 2002 and is now a Director of Westerly Projects Ltd, a consultancy company offering development services to the biopharmaceutical industry globally.

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Sharon Grimster
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Small Scale Biomanufacturing – clinical trials, cell & gene therapies

18 September 2008, Clifton Pavilion, Bristol Zoo Gardens, Bristol

This one day conference, sponsored by bioProcessUK and organised by BioApproaches South West, will cover key, important topics relating to small scale GMP biomanufacturing.
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