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European Biopharmaceutical Review

Investigating Biomolecular Interactions in Neuropathology: The Role of SPR

Understanding the complex biological mechanisms that regulate the function of the brain and central nervous system (CNS) represents a daunting task for life science and drug discovery researchers. The processes underlying the development of the CNS, how we sense and react to our environment and why we suffer from neurodegenerative diseases, are all dictated by cascades of biomolecular interactions. These processes are mediated by a variety of signalling molecules; how and where these molecules interact with their targets is a fundamental focus of research. Therefore new technologies based on surface plasmon resonance (SPR), designed specifically for the study of biomolecular binding events, can be powerful and key tools in neuroscience. Indeed, they are already bringing major benefits to research areas such as nerve cell growth, the connections they make with other nerve cells, the way in which messages are communicated and their response to endogenous and exogenous agents.


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By Stefan Lfs, Vice President and Chief Scientific Officer of Biacore AB Dr Stefan Lfs holds a PhD and a BSc in Organic Chemistry. Having worked for the company since 1985, he has gained extensive technical and scientific experience in the development and commercialisation of bioanalytical instrumentation at Biacore AB.
Dr Lfs has been intensively involved in the development of Biacore's sensor chip chemistry and applications and was recently appointed Chief Scientific Officer with responsibility for technical development projects, external scientific collaborations and technical aspects of the IPR portfolio. Prior to this role, Dr Lfs was Director of Biacore's biochemistry and chemistry department within R&D.

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Stefan Lfs
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