| The last decade has seen substantial progress in the development and application of non-viral vectors in gene therapy. Infectious disease, genetic defects and even traumatic injury may someday be treated with gene therapy and gene transfer strategies. The potential impact of this new technology on human disease has produced optimism and expectation for scientists and lay people alike. As more effort is directed at developing the potential of this technology, it has become evident that the success or failure of gene therapeutic approaches will centre on the ability to manipulate and control the process of genetic transfer into somatic cells. |