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European Biopharmaceutical Review

The Splice of Life

Converting knowledge derived from genomics into therapeutics was never going to be straightforward. Simply knowing the number and sequence of genes in the human genome is not enough. Instead, researchers need to understand the functions of the huge diversity of proteins produced by this genetic code, as proteins are responsible for most cellular activities and form the majority of drug targets.

This is one reason for the huge growth in proteomics research, as researchers try to elucidate cellular events at the level of proteins. However, proteomics requires studies on a far greater scale than genomics. This is due to the vast number of different proteins produced by post-translational modifications, polyadenylation (1) and, perhaps most importantly, the way in which RNA is processed.


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By Fabien Schweighoffer PhD, Executive Vice-President of Therapeutic Programs at ExonHit Therapeutics Dr Fabien Schweighoffer is one of the founders of ExonHit Therapeutics. Previous to this he was employed as a Research Scientist in the Molecular Biology department of Rhфne-Poulenc Rorer (now Aventis) for 10 years.
Fabien holds a PhD in Biochemistry from the University of Paris, has published many papers and received several awards..

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Dr Fabien Schweighoffer
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