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European Biopharmaceutical Review

Effective Gene Transfer in Neurobiology

The potential of gene therapy is now being realised, with therapeutic success in single gene inherited immunodeficiency disorders, and positive clinical progress in a number of other fields including cancer. Gene therapy is also showing great potential in the treatment of nerve injuries and neurodegenerative disorders, as solutions to some major challenges are found. The most fundamental challenge has been to achieve safe and efficient delivery of genes into the right cells in vivo. This article reviews the vectors available for gene therapy in neurobiological applications and examines potential gene therapy approaches for neurodegenerative disease and nerve regeneration.


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Professor Alan Kingsman, Chief Executive Officer and Co-Founder of Oxford BioMedica plc, is an internationally-recognised authority on gene expression and retrovirus research and has over 20 years' experience in this field.
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Professor Alan Kingsman
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