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European Biopharmaceutical Review

Calorimetry Takes the Heat Off Drug Discovery

There are two essential steps at the beginning of the process of bringing a drug compound to market; the identification of a lead compound, and the optimisation of this lead compound to hone the required characteristics - including its affinity - for its specific target. The modern pharmaceutical industry is involved in a continuous search for ways of streamlining these two steps to increase yields, save time and reduce costs. As a result, there has been a pressure to develop the capabilities of instrumentation to assist in these processes. The recent revolution in the development of calorimetric instrumentation (and its applications) has enabled it to assume a position in the frontline of the battle to develop pharmaceutical products.


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By Dr John Ladbury, Wellcome Trust Senior Research Fellow in the Department
of Biochemistry and Molecular Biology at University College London

A graduate in Chemistry and Physics from the University of London, John Ladbury went on to receive his PhD in Inorganic Polymer Chemistry from the University of Greenwich in 1990. John held postdoctoral appointments at Yale University, Harvard University Medical School and New York University Medical Center before taking up a Wellcome Trust Career Development Research Fellowship at the University of Oxford in 1994. He received a Wellcome Trust Senior Fellowship after moving to the Department of Biochemistry and Molecular Biology at University College London. John's laboratory at UCL adopts a multi-disciplinary approach to understanding thermodynamic/structural correlation in the interactions of proteins. His group is currently involved in drug development projects on inhibitors of intracellular signaling pathways and novel antibacterial targets.

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Dr John Ladbury
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