spacer
home > ebr > summer 2007 > hiv: drug market dynamics
PUBLICATIONS
European Biopharmaceutical Review

HIV: Drug Market Dynamics

Mansi Shah and Lisette Oversteegen at DataMonitor investigate the market potential of HIV retrovirals and predict the impact of patent expiry

Ever since the discovery of the human immunodeficiency virus (HIV) in 1984, the prevalence of HIV patients has been increasing worldwide, and by 2006 there were 39.5 million with the disease (1). The six major Western markets (6MM) (2) represent the largest HIV drug market, generating approximately $8.2 billion of sales in 2006, following a strong compound annual growth rate (CAGR) of 13.1 per cent between 2003 and 2006 (3).

Although small compared to sectors such as the antibacterial market, the HIV market is one of the fastestgrowing within the infectious diseases sector. Factors driving this growth include the growing number of heterosexual transmissions, immigration from countries with a high HIV prevalence, and a suggested increase in high-risk sexual behaviour among homosexual men. At the same time, the lifeprolonging effects of antiretroviral therapies have turned HIV into a chronic disease.

Although the 6MM represent the most commercially significant HIV markets, they account for only three to six per cent of the globally infected population – over 95 per cent of HIV patients live in the developing world, with sub-Saharan Africa accounting for the vast majority (4). The growth in patient numbers in the Western markets is lower than the six per cent global growth in patient population from 2004 to 2006 as a result of greater disease awareness (1). Meanwhile, growth in emerging markets is driven by the fact that there are fewer and less well-funded HIV/AIDS educational programmes, the drug distribution infrastructure is less effective and drugs are unaffordable for patients.

COMBINATION DRUGS

The HIV market has witnessed a rapid development since the introduction of the first antiretroviral in 1987 (GlaxoSmithKline’s Retrovir, zidovudine). This drug belongs to the nucleoside reverse transcriptase inhibitor class (NRTIs). Since this was the first class of antiretrovirals to become available, the majority of patients were placed on high doses of monotherapy, which eventually led to toxicity and resistance. The introduction of protease inhibitors (PIs) in 1995 provided physicians with extra options to treat patients and initiated the use of a combination of drugs from different classes, more commonly known as highly active antiretroviral therapy (HAART).

This class’s novel mechanism of action enabled synergistic action with NRTIs in combination therapy, which partly addressed the problem of resistance. However, there were a number of issues when the first PIs launched, including patient compliance due to high pill burden, pharmacokinetic problems and side effects – such as lipodystrophy, liver toxicity and diabetes. Recently launched PIs have been designed to address these issues: drugs such as Kaletra, Reyataz and Prezista (developed by Abbott Laboratories, Bristol Meyers-Squibb (BMS) and Tibotec respectively) have more favourable side-effect profiles and have a significantly lower pill burden compared to the older PIs.


Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
Mansi Shah joined Datamonitor in 2006 as an Associate Analyst and has since authored a number of market analysis reports for the company in the field of infectious diseases, focusing in particular on HIV, respiratory tract infections and nosocomial infections. She is now an HIV/Infectious Diseases Analyst. Prior to Datamonitor, Mansi completed a BSc (Hons) degree in Natural Sciences at Birmingham University, majoring in Biochemistry and Maths.

Lisette Oversteegen joined Datamonitor in October 2005 and has since focused on market analysis in the field of infectious and respiratory diseases, including HIV, respiratory syncytial virus, asthma, COPD, cystic fibrosis and allergic rhinitis. She is now an HIV/Infectious Diseases Analyst. Prior to Datamonitor, Lisette completed a Master’s in Public Health at Maastricht University, the Netherlands, specialising in work and health, and a Bachelor’s in Occupational Therapy, at Amsterdam University.

spacer
Mansi Shah
spacer
spacer
spacer
Lisette Oversteegen
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Vaisala Introduces CAB100 Industrial Cabinet for Cleanrooms

Vaisala, a global leader in weather, environmental, and industrial measurements, launches its newest offering for centralized environmental monitoring in cleanrooms: The CAB100 integrates Vaisala’s world-class instruments for monitoring parameters into a simple, pre-configured enclosure.
More info >>

White Papers

Value-Added Processing and Quality By Design Principles Help Meet High-Quality Demands

West Pharmaceutical Services, Inc.

The current pharmaceutical market has faced a variety of challenges, including increasing expectations for quality from end-users and regulatory agencies driven by concern for patient safety. While pharmaceutical companies are working to assure that new quality and compliance paradigms are met, a balance must be achieved between the reality of managing costs in an effort to provide a product that meets the requirements of payers along with facilitating profitability in order to continue adequate business reinvestment.
More info >>

 
Industry Events

DIA 2019 Global Annual Meeting

23-27 June 2019, San Diego Convention Center

DIA 2019 is more than just a meeting: it’s where brilliant minds come together to create solutions. Thousands of global innovators will convene to engage in discussions on today’s hottest topics in the life sciences field, propose ways to combat daily challenges, and network to create lasting connections.
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement