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European Biopharmaceutical Review
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| Monica Cardona at Pall Life Sciences investigates techniques for increasing yield in mammalian and microbial cell culture applications using enriched and pure gaseous oxygen
Many valuable biopharmaceutical and biotechnological products are produced by aerobic fermentation, which includes mammalian and microbial cell culture applications. Worldwide demand for fermentation products has been increasing steadily, and this trend is expected to continue. To improve productivity, manufacturers are trying to run high-strength broths with higher biomass levels to achieve larger product yields. Because of this trend, and the fact that eliminating oxygen starvation phases can increase bioreactor and fermenter yields, improved aeration concepts have recently been established to satisfy the additional oxygen demands of fermentation and cell culture unit operations.
Modern aeration increasingly uses enriched or pure gaseous oxygen to improve cell culture productivity. Sterilising grade gas filters that can be integrity-tested by means of a water intrusion test (WIT) are the best way to prevent spoilage of bioreactors and fermenters by organisms and contaminants in incoming and outgoing air and oxygen streams.
However, many materials, such as organic matter, plastics or metals, can potentially ignite when they come into contact with oxygen, particularly if they are also subjected to static discharges, high temperatures, pneumatic shocks or mechanical impact. In addition to the aforementioned safety aspects, oxygen or enriched oxygen gases can lead to accelerated oxidation or corrosion of component materials. |
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News and Press Releases |
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CPhI China opens with analysis pointing to a surge in growth in 2019
Shanghai, 23rd May 2019: New analysis released ahead of CPhI & P-MEC China (#CPhIChina and #PMECChina) – co-organized by Informa Markets, CCCMHPIE, and Shanghai Sinoexpo Informa Markets – forecasts that China will continue to grow strongly through 2019/20, thanks in part to a marked improvement in its global reputation.
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Smaller, Smarter, Electronic, Connected: The Next Generation of Drug-Delivery Devices
Phillips-Medisize
An exciting trend in drug delivery is underway: the movement toward smaller, smarter, wirelessly connected electronic devices that allow patient-administered therapy. Inspired by the technological advancements driving the consumer electronics market, new methods for drug delivery show great promise for all stakeholders. Patients wishing to claim more autonomy over their drug regimens, caregivers and medical professionals wanting to more closely monitor drug compliance, health insurance organizations looking to keep costs down, and developers of pharmaceutical products interested in conducting better managed
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Industry Events |
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Nordic Life Science Days 10/12 September 2019
10-12 September 2019, Malmo Sweden
Nordic Life Science Days is the largest Nordic partnering conference for the global Life
Science industry.
Bringing together the best talents in Life Science, offering amazing networking and
partnering opportunities, providing inputs and content on the most recent trends.
Nordic Life Science Days attracts leading decision makers from the Life Science sector,
not only from biotech, pharma and medtech but also from finances, research, policy and
regulatory authorities.
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