spacer
home > ebr > summer 2007 > air fermentation: risks and benefits
PUBLICATIONS
European Biopharmaceutical Review

Air Fermentation: Risks and Benefits

Monica Cardona at Pall Life Sciences investigates techniques for increasing yield in mammalian and microbial cell culture applications using enriched and pure gaseous oxygen

Many valuable biopharmaceutical and biotechnological products are produced by aerobic fermentation, which includes mammalian and microbial cell culture applications. Worldwide demand for fermentation products has been increasing steadily, and this trend is expected to continue. To improve productivity, manufacturers are trying to run high-strength broths with higher biomass levels to achieve larger product yields. Because of this trend, and the fact that eliminating oxygen starvation phases can increase bioreactor and fermenter yields, improved aeration concepts have recently been established to satisfy the additional oxygen demands of fermentation and cell culture unit operations.

Modern aeration increasingly uses enriched or pure gaseous oxygen to improve cell culture productivity. Sterilising grade gas filters that can be integrity-tested by means of a water intrusion test (WIT) are the best way to prevent spoilage of bioreactors and fermenters by organisms and contaminants in incoming and outgoing air and oxygen streams.

However, many materials, such as organic matter, plastics or metals, can potentially ignite when they come into contact with oxygen, particularly if they are also subjected to static discharges, high temperatures, pneumatic shocks or mechanical impact. In addition to the aforementioned safety aspects, oxygen or enriched oxygen gases can lead to accelerated oxidation or corrosion of component materials.


Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
Monica Cardona has been with Pall Corporation since 1996. She worked as a Laboratory Analyst and as a Senior Laboratory Analyst in the microbiology laboratory. She then joined the validation group as a Validation Project Manager for compatibility and extractables projects. Today, Monica is a Marketing Manager with responsibility in the western hemisphere for direct flow filtration. She holds a BA in Biology from Hofstra University and an MA in Biology from Adelphi University.
spacer
Monica Cardona
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

CPHI Frankfurt returns to pre-pandemic strength as pharma industry booms again

Amsterdam, 8th December 2022 - The global pharma industry was out in full force at CPHI Frankfurt in November with 40,405 executives from 167 countries visiting the 2022 edition of the world-leading pharma industry tradeshow, a huge 75% increase over the number of attendees in 2021. Final visitor numbers will be confirmed by independent auditors ABC in early 2023.
More info >>

White Papers

What You Need To Know About Thermal Shipping Technologies

Temptime Corporation

This paper presents highlights from a thermal performance study conducted by Modality Solutions LLC. The study examined the performance of five shipping technologies commonly used by specialty pharmacies to transport high-value refrigerated specialty medicines against an industry accepted temperature profile standard.
More info >>

 

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement