In the past year, major new developments in cutting-edge, highend mass spectrometers and mass spectrometry-based software solutions have reached research scientists in the pharmaceutical and biotechnology industries, positively impacting their research. A new generation of proteomics data warehousing, proteomics data mining and proteomics project management software is now in use by research scientists, especially in Europe. Secondly, new tools for biologics drug development have become available. In addition, mass spectrometry-based metabolic profiling is now combining complementary methods of metabolite quantitation and structure determination by nuclear magnetic resonance (NMR) with exact mass analysis by electrospray mass spectrometry (ESI-MS). Furthermore, new generations of highend mass spectrometers have now become particularly useful to pharma and biotech researchers dedicated to drug discovery and development, especially when coupled with the latest advanced solutions in MALDI molecular imaging of human and research model tissues, along with software solutions for biomarker panel discovery, identification and validation, for example.

NEW PROTEOMICS DATA WAREHOUSING AND PROJECT MANAGEMENT SOFTWARE PRODUCE POSITIVE PROTEIN RESEARCH RESULTS

With a new generation of proteomics data warehousing software now in use, next-generation bioinformatics platforms addressing scientists’ current needs in proteomics identification and biomarker profiling, quantification and validation have become available. As a comprehensive solution for qualitative and quantitative liquid chromatography (LC)-MS/MS protein analysis, such proteomics software can now support all current label chemistries including multiplexed labels, as well as label-free quantification. Interactive validation of protein quantification based on raw LC/MS data has become simple and straightforward, streamlining the discovery process through decoy auto-validation algorithms and algorithms that produce non-redundant protein result lists across entire proteomics projects, including brain proteomics projects.