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European Biopharmaceutical Review
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| Flow cytometry is a technique for cell characterisation that is popularly used
in basic and translational research for understanding, for example, how mutated
stem cells may confer therapy resistance to a tumour (1). Alternatively, cell
characterisation can be used to measure cell receptors during activation or as
a response to immunosuppressive drugs. A flow cytometer consists of a narrow,
hydrodynamically-focused stream of cells that pass and are interrogated by a light
source. The cells’ physical characteristics of size and granularity, as well as any
fluorescent labels attached in or on the cells, scatter the beam of light. Fluorescent
labels attached will then be excited, enabling the appropriate emission
characteristics to be measured in relative terms of fluorescent intensity.
Flow cytometer manufacturers have responded to the needs of
modern researchers by developing faster systems that can measure
more variables over shorter time periods for applications such as
detecting tumour cells in peripheral blood and examining different
aspects of stem cell differentiation. However, the ability of the
software that flow cytometers rely on to analyse and visualise the
rapidly rising tide of data now being generated has lagged way
behind these improvements in instrument technology. This article
examines some of the approaches that enlightened software
manufacturers are now taking to speed up and simplify data
analysis and support the revolution in flow cytometry research. |
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News and Press Releases |
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Quanterix Launches the First Comprehensive Multiplex Panel to Study Traumatic Brain Injury Severity
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White Papers |
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The Impact of Components on Drug Quality and Risk Mitigation
West Pharmaceutical Services, Inc.
Expectations for quality by regulatory agencies are increasing at a very fast pace, especially for prefilled drug delivery formats, thanks to increased focus on reducing risk to patient safety. The trend has resulted in delays for new drug applications, more recalls of marketed products and even drug shortages if the container system and drug contents are suspect for quality issues. The pharmaceutical market is now requiring manufacturers of containers and components to meet new expectations with a quality culture and very high product reliability. The need to bridge the gap and provide superior quality products has been a driver for manufacturing technology investments, more robust control strategies and the introduction of next generation elastomer components.
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Industry Events |
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BioPharm America™ 2017—10th Annual International Partnering Conference
26-27 September 2017, 39 Dalton Street, Boston, MA 02116
BioPharm America™ is a unique partnering event that forms the nexus of discovery and realization. Startup companies, established biotech and entrepreneurs from academia attend in search of finance, pharma and development partners.
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