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International Clinical Trials

Modifying Methods

ICT: Why has there recently been more interest in adaptive trials?

Dr Sy Pretorius: The UK government announcing a 40 million investment in the Dame Tessa Jowell Brain Cancer Research Mission which includes speeding up the use of adaptive trials to test different treatments at the same time and streamlining the process has shed a new spotlight of media interest on the topic, but several reasons exist for this for broader increased interest as well.

For one, regulatory agencies especially the FDA in the US and EMA in Europe are encouraging the use of adaptive trials. Both of these agencies have been supportive in terms of their comments around the use of the adaptive designs where appropriate. Additionally, several recent statistical and technological advancements have made these trials more viable.

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Sy Pretorius MD leads Medical and Scientific Services at PAREXEL. In this role, Sy collaborates with biopharmaceutical and medical device clients in designing and optimising drug/device development strategies and plans, as well as finding, evaluating, and purchasing assets. He is passionate about drug development, leading several initiatives on clinical trial innovation. Sy is a medical doctor with Master's degrees in clinical pharmacology, business administration, and the management of drug development.
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