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International Clinical Trials

Everybody Wins

Providing sites with the communication tools to engage and retain patients is crucial contend Janet Jones at Kendle and Val Lyness at ICR, as they explore holistic approaches to patient-centric recruitment and retention

“What’s in it for me?” Nine times out of 10, it’s the first thing a patient will think about when considering whether or not to participate in a clinical study. As an industry, we’re well aware of this, but are we giving patients the right answers? Are we approaching patient recruitment and retention in the best way possible?

WHAT HAPPENS WHEN THE SITE’S DATABASE IS EXHAUSTED?

There are several steps that can be considered when a site’s database has become exhausted, such as referrals from colleagues, the involvement of advocacy or patient support groups, community outreach with flyers and mailings and direct-to-patient communications. Recruitment planning needs to be considered at several levels ranging from providing siteby- site recruitment plans through to conducting a full directto- patient media campaign.

Sites need to be encouraged to start thinking about the next contingency plan early in the process, not when the failure to recruit has become a major issue. CRAs and the project team can help the sites to develop specific recruitment plans, and to constantly think about the next step and how to overcome recruitment barriers.


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Dr Janet Jones, Director of Global Patient Access and Retention, joined Kendle in 2000 and has overall responsibility for Kendle’s integrated patient recruitment and retention programs. With more than 20 years’ experience in clinical research, she has gained a wealth of industry expertise as a CRA, lead CRA and project manager. Janet is a widely-published molecular geneticist and patient recruitment and retention expert, with a doctorate in molecular biology.

Val Lyness is a leading figure within the Institute of Clinical Research (ICR) having been Chairman of the Board from 1997 until 2000. She is an active member of the ICR Advisory Group that provides guidance to ICR on consultations and current issues. As one of the longest-serving members, she is now an Honorary Fellow of the ICR with more than 20 years’ experience as a clinical research professional.

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Janet Jones
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Val Lyness
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Industry Events

4th Annual Patient Recruitment and Retention in Clinical Trials

13-15 October 2008, Amsterdam

Patient recruitment is now consuming thirty percent of clinical trial time - more time than any other clinical trial activity - and almost half of all trial delays result from patient recruitment problems. As the recruiting culture becomes more sophisticated and the forces affecting patient enrollment grow more numerous and complex, pharmaceutical companies are striving to discover new strategies to facilitate enrollment in clinical trials. With increasing industry pressure to develop, test and market greater numbers of new drugs faster, pharmaceutical companies need to perform clinical trials as quickly as possible. Inefficient patient recruitment processes is a formidable barrier to pharmaceutical companies' success in launching new products. Improving the patient recruitment process is imperative to avoid wasted investments and eliminate costly delays in bringing new drugs to market -- today and even more so in the not-so-distant future. Improved patient recruitment presents one of the largest opportunities for pharmaceutical companies to eliminate delays in clinical trials, thereby making it possible to reduce time to market.  With patent time limits and large overheads meaning that any delays in the development timeline can be disastrous, a good understanding of how to successfully recruit patients for trials is vital for any company looking to succeed.
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