spacer
home > ict > spring 2008 > brain power
PUBLICATIONS
International Clinical Trials

Brain Power

Is a clinical trial without computerised cognitive testing brainless? Mark Cusack of CDR presents a system that can add value to trial programmes

Technological development presents a vast array of inviting possibilities for using automated cognitive testing within clinical trials. Promising quick, clean, empirical data at minimal inconvenience to the investigator and subject alike, automated cognitive testing also provides greater operational efficiencies and scientific insight.

This article aims to raise awareness of the possibilities of computerised cognitive testing by referring to first principles and establishing that when the technology is serving the science, real value and insight can be added to virtually any clinical trial programme. Specifically, why use automated cognitive testing? What are the reasons and where are the advantages? How do these relate to the different phases of clinical development? Can they generate early indications of efficacy? The author hopes to challenge current paradigms raising the prospect of scope and value that can be added by employing these systems beyond what would traditionally be considered as cognitive testing’s therapeutic footprint, and reflect briefly on what the regulatory authorities require.

WHY AUTOMATE COGNITIVE TESTING IN TRIALS

Numerous tests have shown that automated cognitive testing, in the right hands, can be superior to traditional paper and pen (P&P) measures such as the ADAS-cog, the digit symbol substitution test (DSST) and the mini mental state exam (MMSE). The test battery employed would need certain key elements such as: sensitivity in differentiating effects versus the traditional P&P tests; greater sensitivity than self ratings; being closely related to P&P measures; and have superior psychometric properties for certain conditions for example, Alzheimer’s disease. It would need to be objective as it is inherent within automated testing.


Read full article from PDF >>

Rate this article You must be a member of the site to make a vote.  
Average rating:
0
     

There are no comments in regards to this article.

spacer
Mark Cusack is Head of Business Development (Europe and Asia) at Cognitive Drug Research. Mark graduated with a BSc (Hons) in Business Economics with Computing from the University of Surrey. He started his career in the futures market in the City of London, after which he worked in business development and marketing roles in both the FMCG and internet sectors, latterly in marketing for Coca-Cola. Mark moved into the life sciences industry, working in late-phase business development for a full service global CRO, and is now Head of Business Development (Europe and Asia) for Cognitive Drug Research
spacer
Mark Cusack
spacer
spacer
Print this page
Send to a friend
Privacy statement
News and Press Releases

Nemera acquires Insight Product Development to strengthen its capabilities

“Every day at Nemera, we work to improve the lives of millions of patients worldwide by designing, developing and manufacturing innovative drug delivery devices. Our vision as a team is to become the most patient-centric drug delivery device company in the industry. We partner closely with our customers to deliver innovative and high quality devices, to ensure that patients will receive the best product and service possible” Marc Hämel, CEO
More info >>

White Papers

Advantages of Quantitative NMR for the Determination of Relative Response Factors

Novatia, LLC

Quantitative NMR (qNMR) is a technique that is being applied broadly and at an increasing rate in the field of pharmaceutical analysis (1). This white paper highlights the advantages of using qNMR to determine Relative Response Factors (RRFs) for pharmaceutical impurities detectable by HPLC. A single determination of RRFs using qNMR allows for simple and accurate quantitation of impurities which eliminates the need for preparation, qualification, and storage of reference standards. An example is presented here, which demonstrates quantitation of known impurities that have variable responses to UV-VIS detection, thereby providing a more accurate assessment of impurity levels than UV-VIS response alone.
More info >>

 
Industry Events

SCOPE Summit for Clinical Ops Executives

18-21 February 2020, Hyatt Regency, Orlando, Florida, US

Celebrating its 11th successful year, SCOPE Summit 2020 takes place February 18-21 in Orlando, FL. Over the course of four stimulating days of in-depth discussions in 20 different conferences, 3 plenary keynote sessions, the annual Participant Engagement Awards, and the ever-popular interactive breakout discussions, the programming focuses on advances and innovative solutions in all aspects of clinical trial planning, management and operations
More info >>

 

 

©2000-2011 Samedan Ltd.
Add to favourites

Print this page

Send to a friend
Privacy statement