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Pharmaceutical Manufacturing and Packing Sourcer

Perfect Polymers

Drug delivery materials can help pharmacotherapy by use of polymers to stabilise medication during both production and sterilisation in order to obtain the desired pharmacokinetics, or to achieve locally controlled and targeted drug delivery (1).

Polymers are the preferred matrices for controlled drug delivery, because of the large degree of variables that can be used to tune release, in addition to their other functional properties. Polymers may be divided into linear (thermoplastic) or cross-linkable (thermoset) polymers. In both of these two classes, the composition of the polymer can be tuned further to give random, alternating or block copolymers. Yet another feature to control drug release is the molecular architecture that can be used to generate linear, branched, hyperbranched and comb-like polymers. Finally, polymers can be formulated either as linear polymer blends, linearcrosslinked polymer blends (semiinterpenetrating networks) and blends of cross-linked polymers (interpenetrating networks).


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Aylvin A Dias, PhD, is R&D Manager at DSM Biomedical, Geleen, the Netherlands. He currently manages research in drug delivery and tissue engineering for ophthalmic and cardiovascular applications. He obtained his BSc and PhD in Biological and Polymer Chemistry at the University of Kent. After completing his PhD in 1994, he worked at Total Chemie on materials for food packaging. In 1996 he joined DSM in the Netherlands. In his first five years there, he worked on optical fibre and stereolithographic materials. In the subsequent four years, he established the biomedical research programme and became co-founder of DSM Biomedical. He managed the start-up of an application development laboratory in medical coatings. The research programme led to the launch of two new medical coatings: a lubricious coating and an antimicrobial coating. Aylvin has over 30 patents and 20 peer-reviewed publications.

Marc Hendriks joined DSM Biomedical Materials in 2006, after serving for almost 15 years at Medtronic’s Bakken Research Center in Maastricht, the Netherlands. In his current position as R&D/Technology Director, Marc takes care of DSM Biomedical’s scientific R&D programme and the formation of technology strategies, including the alignment of these with business and intellectual property strategies. He also leads the development of strong cooperative relationships with key knowledge institutes around the world. Marc graduated from Eindhoven University of Technology in 1992, received his PhD in Chemical Technology from the same institute in 1996, and his cum laude MBA degree from the University of Maastricht Business School in 2005. Hendriks holds more than 25 US Patents, with several more pending, and has (co-)authored various publications and book chapters in the field of biomedical materials research.

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Aylvin A Dias
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Marc Hendriks
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