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Pharmaceutical Manufacturing and Packing Sourcer

Quality: Compacted

A roller compaction method creates the opportunity to use glucose monohydrate as a single high-performance excipient in direct compression tabletting, functioning as a diluent-binder in tablets containing high levels of actives.

Compressed tablets are the most widely used solid dosage form for medicinal ingredients. They are convenient, easy to use, portable, available in different sizes and shapes, plus they can deliver active ingredients more accurately than other oral dosage forms.

However, final tablet forms must satisfy a number of physical requirements in terms of hardness, disintegration ability, friability and uniformity (1). In order to provide these tablet characteristics in accordance with the chosen ingredients, manufacturers can choose between three different processing technologies: direct compression, dry granulation and wet granulation. Table 1 demonstrates the different steps needed for each processing technology to manufacture the tablet (1-3).

 


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Katleen Brys is a Pharma & Personal Care Application Specialist at the Cargill R&D Centre Europe in Vilvoorde, Belgium. She holds a Bachelorís degree in Pharmaceutical Science and a Masterís degree in Biotechnology, and has worked within Cargill for five years. She specialises in formulations and techniques for solid and liquid dosage forms.
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