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Formulating a Plan

High doses are often necessary to deliver enough of an orally administered drug to the lungs or nasal passages through the bloodstream. As many medicines are now highly potent, delivery by mouth has the potential to cause severe side effects. Combined with this, when products are taken in this way they are easily metabolised, which means that they are not always adequately administered to the nose or lungs, thus limiting the success of the treatment.

In contrast, inhalation formulations enable pharmaceuticals to be delivered directly to the nasal passages or lungs in smaller doses, reducing the risks of both side effects and drug-to-drug interaction. Their growth in popularity can further be attributed to their ability to give the most direct access to a drug target. For example, many inhaled products are steroid drug classes. They can have a harmful impact on growth and hormone balance if taken in large amounts by children and is, therefore, beneficial to deliver a smaller dose to the site of action.

These local therapies offer fast absorption, rapid response and enable a drug to be administered straight to the conducting zone of the lungs. As a result, they work particularly well for conditions such as asthma. Inhalation also represents a very attractive way to deliver drugs to the brain. In the treatment of migraines, for instance, nasal spray drug delivery into the nose can bring fast and effective relief.

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Poonam Aliyah Sheth is a Research Scientist specialising in inhalation product development at Recipharm and she holds a PhD in Pharmaceutical Science from the University of Arizona, US. With particular expertise in MDI formulations, dry powder inhalers and nebulised formulations, she has been integral to the development and manufacture of many original and generic products for inhalation drug delivery for global clients, ranging from emerging to large pharmaceutical organisations.

Ramil Menzeleev, PhD, is Director of Recipharm’s Analytical Sciences department. He oversees analytical method development, providing scientific review for client projects while also participating in the design and development of electronic data recording software platforms. A specialist in analytical chemistry, his expertise covers fast, highly sensitive, accurate and high-throughput quantitation method development. He also manages the selection and implementation of IT solutions, including software for business process management, as well as review and approval software for design, validation, implementation and use in Good Manufacturing Practice environments.
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Poonam Aliyah Sheth
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Ramil Menzeleev
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